ECE-2 Protein, Human (HEK293, hFc)

The ECE-2 protein plays a crucial role in vascular regulation by catalyzing the conversion of large endothelin-1 to endothelin-1, helping to regulate blood pressure and vascular tone. Furthermore, ECE-2 exhibits potential methyltransferase activity and may be involved in amyloid-β processing, suggesting that this enzyme has a broader impact on cellular function than its established role in endothelin processing. ECE-2 Protein, Human (HEK293, hFc) is the recombinant human-derived ECE-2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of ECE-2 Protein, Human (HEK293, hFc) is 685 a.a., with molecular weight of 120-130 kDa.

The ECE-2 protein is an essential enzyme with dual functionality. Primarily, it plays a crucial role in converting big endothelin-1 to endothelin-1, a biologically active peptide involved in the regulation of vascular tone and blood pressure. In addition to its role in the endothelin system, ECE-2 exhibits potential methyltransferase activity, implying its involvement in the transfer of methyl groups between molecules. Moreover, there is a suggested role for ECE-2 in amyloid-beta processing, indicating a possible association with processes related to neurodegenerative conditions. The multifaceted nature of ECE-2's activities underscores its significance in both cardiovascular physiology, through endothelin processing, and potential contributions to molecular events associated with neurodegenerative disorders (

Human

HEK293

N-hFc

P0DPD8 (G199-W883)

110599583  [NCBI]

120-130 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.