Endoglycan/PODXL2 Protein, Human (HEK293, His)

Endoglycan/PODXL2 Protein, acting as a ligand for vascular selectins, enables the rapid rolling of leukocytes over vascular surfaces by engaging in high-affinity divalent cation-dependent interactions with E-, P-, and L-selectins. Through disulfide linkages, the protein forms homodimers and interacts with specific selectin proteins, including SELL, SELE, and SELP. These interactions highlight its pivotal role in mediating adhesive events crucial for leukocyte recruitment and vascular homeostasis. Endoglycan/PODXL2 Protein, Human (HEK293, His) is the recombinant human-derived Endoglycan/PODXL2 protein, expressed by HEK293, with C-His labeled tag. The total length of Endoglycan/PODXL2 Protein, Human (HEK293, His) is 468 a.a., with molecular weight of 70-115 kDa.

Endoglycan/PODXL2 Protein functions as a ligand for vascular selectins, facilitating the rapid rolling of leukocytes over vascular surfaces by engaging in high-affinity divalent cation-dependent interactions with E-, P-, and L-selectins. It forms homodimers through disulfide linkages and interacts with specific selectin proteins, including SELL, SELE, and SELP. These interactions underscore its role in mediating crucial adhesive events that contribute to the intricate processes of leukocyte recruitment and vascular homeostasis.

Human

HEK293

C-His

Q9NZ53 (G33-T500)

50512  [NCBI]

70-115 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.