PODXL2 - podocalyxin like 2 Gene

Also Known as EG; PODLX2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50512

About PODXL2

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,629,185-127,672,802 (from NCBI)

This gene has 1 transcript (splice variant) and 169 orthologues. Broad expression in brain (RPKM 27.2), testis (RPKM 16.2) and 16 other tissues.

Summary

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular Mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]

PODXL2 Products (1)

mRNA Protein Name
NM_015720.4 NP_056535.1 podocalyxin-like protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18606703 GOA
Biological Process GO Annotation Evidence References Source
involved in leukocyte tethering or rolling IDA
IDA: Inferred from direct assay
18606703 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PODXL2 Protein Structure

CD34_antigen

CD34_antigen: CD34/Podocalyxin family (393 - 605)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
Protein Preferred Names Protein Names

podocalyxin-like protein 2

  • endoglycan

Recombinant PODXL2 Proteins

Cat. No. Product Name Accession Purity
HY-P78020 Endoglycan/PODXL2 Protein, Human (HEK293, His) Q9NZ53-1 (G33-T500) ≥ 95%, as determined by Bis-Tris PAGE.

PODXL2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811041 Endoglycan Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type

  • Methylcobalamin Deficiency, Cblg Type

  • HMAG

  • Methionine Synthase Deficiency

  • Methylcobalamin Deficiency Type Cblg

  • Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type

  • Homocystinuria-Megaloblastic Anemia Cblg Type

  • Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type

  • Methylcobalamin Deficiency Cbl G Type

  • Homocystinuria Due To Defect In Methylation Cbl G

  • Cblg

  • Functional Methionine Synthase Deficiency Type Cblg

  • Methylcobalamin Deficiency Cblg Type

  • Arakawa Syndrome 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10809 PODXL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20582 Podxl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27090 Podxl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PODXL2 VGNC VGNC:44765
Macaca mulatta PODXL2 VGNC VGNC:76056
Felis catus PODXL2 VGNC VGNC:64275
Rattus norvegicus PODXL2 RGD RGD:1305815
Bos taurus PODXL2 VGNC VGNC:33103
Mus musculus PODXL2 MGD MGI:2442488
Others PODXL2 NCBI