ENPP-3 Protein, Canine (HEK293, His)

ENPP-3 is a hydrolase that plays a crucial role in regulating the immune response. ENPP-3 plays an important role in tumor development and invasion. The hypomethylation of the ENPP-3 promoter region is involved in the occurrence and progression of ovarian endometriosis through the AKT/mTOR/4EBP1 signaling pathway. ENPP-3 Protein, Canine (HEK293, His) is the recombinant canine-derived ENPP-3 protein, expressed by HEK293 , with N-His labeled tag.

ENPP-3 is a hydrolase with the ability to metabolize a variety of extracellular nucleotides, including ATP, GTP, UTP, and CTP. This enzyme activity plays a crucial role in regulating the immune response, especially during the chronic stages of inflammation and allergic reactions. ENPP-3 is a protein detected in the womb that plays an important role in tumor development and invasion. The hypomethylation of the ENPP-3 promoter region is involved in the occurrence and progression of ovarian endometriosis through the AKT/mTOR/4EBP1 signaling pathway^[1][2][3].

Canine

HEK293

N-8*His

A0A8I3N0F5 (R46-I874)

/

Partial

RRQEEQGSCRKKCFDSSFRGLENCRCDMECKQRGDCCWDFEDTCVESTRIWTCNRFRCGETRLESSLCSCSDDCLQRKDCCTDYKSVCQGETPWVKEECGTAQQSECPEGFELPPVILFSMDGFRAEYLQTWDALIPNINKLKTCGIHSKYMRAVYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNLNFSLSSKEKNNPAWWKGQPIWLTAMYQGLKAGSFFWPGSDVAINGSFPSKYIHYNRSIPYEERISTLLKWLDLPKAERPDFYTIYVEEPDSAGHESGPVSATVIQALQLVDKAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCDKREYMTDYFPRINFYMYEGPAPRIRARNIPHDFYSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHFAKNVRIDKAHLLVDRQWLAVRSKAYSFCGGGNHGYNNEFKSMKAIFLAHGSSFKEKAEIEPFENIEVYNLICDLLHIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFTVPLPTDALDCSCSELQNNTSLEHVNQMLNLPQDQITATEKLNLPFGRPRVMQKNKEHCLLYHREYVSGFGKAIKMPLWSSYTVPKPGDTSLLPPTVPDCLRADVRVAPSESQKCSFYLADQNITHGFLYPPANNRTSDSQYDALITSNLVPMYKAFKKMWDYFHSFLLVKLSMERNGVNVVSGPVFDYNYDGHFDAPNEITGYLTNTSVPIPTHYFVMLTSCKNRSHTPNACPGWLDVLPFIIPHRPTNVESCPEGKPEAVWIEERWQAHVARVRDVELLTGLDFYQEKAQPVSEILQLKTYLPTFETII

Approximately 110-130 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.