ENPP-3 Protein, Canine (HEK293, His)
ENPP-3 is a hydrolase that plays a crucial role in regulating the immune response. ENPP-3 plays an important role in tumor development and invasion. The hypomethylation of the ENPP-3 promoter region is involved in the occurrence and progression of ovarian endometriosis through the AKT/mTOR/4EBP1 signaling pathway. ENPP-3 Protein, Canine (HEK293, His) is the recombinant canine-derived ENPP-3 protein, expressed by HEK293 , with N-His labeled tag.
- Species: Canine
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
ENPP-3 is a hydrolase that plays a crucial role in regulating the immune response. ENPP-3 plays an important role in tumor development and invasion. The hypomethylation of the ENPP-3 promoter region is involved in the occurrence and progression of ovarian endometriosis through the AKT/mTOR/4EBP1 signaling pathway. ENPP-3 Protein, Canine (HEK293, His) is the recombinant canine-derived ENPP-3 protein, expressed by HEK293 , with N-His labeled tag.
Background
ENPP-3 is a hydrolase with the ability to metabolize a variety of extracellular nucleotides, including ATP, GTP, UTP, and CTP. This enzyme activity plays a crucial role in regulating the immune response, especially during the chronic stages of inflammation and allergic reactions. ENPP-3 is a protein detected in the womb that plays an important role in tumor development and invasion. The hypomethylation of the ENPP-3 promoter region is involved in the occurrence and progression of ovarian endometriosis through the AKT/mTOR/4EBP1 signaling pathway[1][2][3].
Technical Parameters
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Species Canine
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Source HEK293
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Tag N-8*His
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Accession
A0A8I3N0F5 (R46-I874)
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Gene ID/
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Molecular Construction
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N-term
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8*His
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ENPP-3 (R46-I874)
Accession # A0A8I3N0F5 -
C-term
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Protein Length
Partial
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Synonyms
ENPP3; B10; Prev. PDNP3; NPPase; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3; NPP3; Phosphodiesterase I/Nucleotide Pyrophosphatase 3; DJ334I18.1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 3); Alkaline Phosphodiesterase I; DJ100
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AA Sequence
RRQEEQGSCRKKCFDSSFRGLENCRCDMECKQRGDCCWDFEDTCVESTRIWTCNRFRCGETRLESSLCSCSDDCLQRKDCCTDYKSVCQGETPWVKEECGTAQQSECPEGFELPPVILFSMDGFRAEYLQTWDALIPNINKLKTCGIHSKYMRAVYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNLNFSLSSKEKNNPAWWKGQPIWLTAMYQGLKAGSFFWPGSDVAINGSFPSKYIHYNRSIPYEERISTLLKWLDLPKAERPDFYTIYVEEPDSAGHESGPVSATVIQALQLVDKAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCDKREYMTDYFPRINFYMYEGPAPRIRARNIPHDFYSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHFAKNVRIDKAHLLVDRQWLAVRSKAYSFCGGGNHGYNNEFKSMKAIFLAHGSSFKEKAEIEPFENIEVYNLICDLLHIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFTVPLPTDALDCSCSELQNNTSLEHVNQMLNLPQDQITATEKLNLPFGRPRVMQKNKEHCLLYHREYVSGFGKAIKMPLWSSYTVPKPGDTSLLPPTVPDCLRADVRVAPSESQKCSFYLADQNITHGFLYPPANNRTSDSQYDALITSNLVPMYKAFKKMWDYFHSFLLVKLSMERNGVNVVSGPVFDYNYDGHFDAPNEITGYLTNTSVPIPTHYFVMLTSCKNRSHTPNACPGWLDVLPFIIPHRPTNVESCPEGKPEAVWIEERWQAHVARVRDVELLTGLDFYQEKAQPVSEILQLKTYLPTFETII
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Predicted Molecular Mass
96.2 kDa
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Molecular Weight
Approximately 110-130 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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