GPR155 Protein, Human (sf9, GFP, Strep, His)
GPR155 Protein, Human (sf9, GFP, Strep, His) is the recombinant human-derived GPR155, expressed by sf9 insect cells , with Strep, His, GFP labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
GPR155 Protein, Human (sf9, GFP, Strep, His) is the recombinant human-derived GPR155, expressed by sf9 insect cells , with Strep, His, GFP labeled tag.
Background
GPR155 is a cholesterol-binding protein that functions as a regulator of the mTORC1 signaling pathway. It acts as a cholesterol sensor to modulate mTORC1 signaling: in the presence of cholesterol, GPR155 binds cholesterol, disrupting the interaction between the GATOR1 and KICSTOR complexes and promoting mTORC1 signaling; under cholesterol starvation, GPR155 fails to perturb the GATOR1-KICSTOR association, leading to mTORC1 inhibition. Additionally, GPR155 binds indole-3-acetic acid and may play a role in tryptophan metabolism. by similar: Studies further highlight GPR155's critical role in cholesterol sensing and mTORC1 regulation.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Strep;His;GFP
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Accession
Q7Z3F1 (M1-T870)
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Gene ID151556
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Protein Length
Full Length
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Synonyms
GPR155; Lysosomal Cholesterol Signaling Protein; G Protein-Coupled Receptor 155; G-Protein Coupled Receptor PGR22; LYCHOS; FLJ31819; PGR22; Integral Membrane Protein GPR155; DEPDC3; Lysosomal Cholesterol Signaling; DEP.7; GPR155 Protein
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AA Sequence
MNSNLPAENLTIAVNMTKTLPTAVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGISLMCMNQTAQAGSYEGFDQSQSHKVVEPGNTAFEESPAPVNEPELFTSSIPETSCCSCSMGNGELHCPSIEPIANTSTSEPVIPSFEKNNHCVSRCNSQSCILAQEEEQYLQSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKDTAENRDSPVSEEIKMTCQQFIHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPAINANTLQQERYKEIEHSSPPSHSPKT
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Predicted Molecular Mass
127.7 kDa
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Glycosylation
Yes
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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