IGFBP-2 Protein, Cynomolgus (HEK293, His)
IGFBP-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP2 protein, expressed by HEK293, with C-His tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
IGFBP-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP2 protein, expressed by HEK293, with C-His tag.
Background
IGFBP2 is a multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors, thereby controlling IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type-specific manner. It functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to modulate IGF1-mediated signaling by stimulating PTEN phosphorylation, leading to its inactivation and AKT1 activation. Additionally, IGFBP2 promotes cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif, while its interaction with ITGA5/ITGB1 enhances endothelial progenitor cell adhesion to endothelial cells. Upon mitochondrial damage, IGFBP2 facilitates apoptosis in podocytes alongside ITGA5 and activates focal adhesion kinase (FAK)-mediated mitochondrial injury phosphorylation.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
A0A2K5WZA2 (G33-Q325)
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Gene ID/
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Protein Length
Full Length of Mature Protein
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Synonyms
IGFBP2; Insulin-Like Growth Factor Binding Protein 2 (36kD); Prev. IBP2; IGF-BP53; Insulin-Like Growth Factor-Binding Protein 2; IGFBP-2; Insulin-Like Growth Factor Binding Protein 2, 36kDa; IBP-2; IGF-Binding Protein 2; BP2; Insulin Like Growth Factor Bi
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AA Sequence
GRAHAEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVAEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ
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Predicted Molecular Mass
32.8 kDa
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Molecular Weight
Approximately 35-45 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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