Immunoglobulin J chain Protein, Mouse (P.pastoris, His)
The Immunoglobulin J chain links IgM or IgA monomers. In IgM, J chain-joined dimers nucleate the IgM pentamer, while in IgA, it induces dimer or polymer formation. It also binds these immunoglobulins to the secretory component. As part of the sIgA complex, it integrates with IgA monomers, the J chain, and the secretory component (PIGR proteolytic product). Immunoglobulin J chain Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Immunoglobulin J chain protein, expressed by P. pastoris , with N-His labeled tag.
- Species: Mouse
- Source: P. pastoris
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The Immunoglobulin J chain links IgM or IgA monomers. In IgM, J chain-joined dimers nucleate the IgM pentamer, while in IgA, it induces dimer or polymer formation. It also binds these immunoglobulins to the secretory component. As part of the sIgA complex, it integrates with IgA monomers, the J chain, and the secretory component (PIGR proteolytic product). Immunoglobulin J chain Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Immunoglobulin J chain protein, expressed by P. pastoris , with N-His labeled tag.
Background
The Immunoglobulin J chain serves as a crucial link connecting two monomer units of either IgM or IgA. In the context of IgM, the J chain-joined dimer acts as a nucleating unit for the IgM pentamer, while for IgA, it induces the formation of dimers and/or larger polymers. Additionally, the Immunoglobulin J chain plays a role in binding these immunoglobulins to the secretory component. It is an integral part of the secretory IgA (sIgA) complex, which comprises two, four, or five IgA monomers and two additional non-Ig polypeptides, namely the J chain and the secretory component (the proteolytic product of PIGR).
Technical Parameters
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Species Mouse
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Source P. pastoris
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Tag N-His
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Accession
P01592 (G22-D159)
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Molecular Construction
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N-term
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His
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J-chain (G22-D159)
Accession # P1592 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
JCHAIN; JCH; Prev. IGJ; IgJ Chain; IGCJ; J Chain; Immunoglobulin J Chain; Joining Chain Of Multimeric IgA And IgM; Immunoglobulin J Polypeptide, Linker Protein For Immunoglobulin Alpha And Mu Polypeptides
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AA Sequence
GDDEATILADNKCMCTRVTSRIIPSTEDPNEDIVERNIRIVVPLNNRENISDPTSPLRRNFVYHLSDVCKKCDPVEVELEDQVVTATQSNICNEDDGVPETCYMYDRNKCYTTMVPLRYHGETKMVQAALTPDSCYPD
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Predicted Molecular Mass
17.7 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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