IP6K1/IHPK1 Protein, Human (sf9, His-GST)
Based on 1 Customer Validation
IP6K1, also known as the IHPK1 protein, plays a crucial role in cell signaling by catalyzing the conversion of inositol hexaphosphate (InsP6) to inositol diphosphate pentaphosphate (InsP7/PP-InsP5). In addition, this enzyme is also involved in the conversion of 1,3,4,5,6-pentaphosphate (InsP5) to PP-InsP4. IP6K1/IHPK1 Protein, Human (sf9, His-GST) is the recombinant human-derived IP6K1/IHPK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
IP6K1, also known as the IHPK1 protein, plays a crucial role in cell signaling by catalyzing the conversion of inositol hexaphosphate (InsP6) to inositol diphosphate pentaphosphate (InsP7/PP-InsP5). In addition, this enzyme is also involved in the conversion of 1,3,4,5,6-pentaphosphate (InsP5) to PP-InsP4. IP6K1/IHPK1 Protein, Human (sf9, His-GST) is the recombinant human-derived IP6K1/IHPK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
Background
The IP6K1/IHPK1 protein is an enzyme that plays a crucial role in inositol phosphate metabolism. It converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5), representing a key step in the synthesis of higher inositol polyphosphates. Additionally, IP6K1/IHPK1 catalyzes the conversion of 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. These enzymatic activities contribute to the intricate regulation of inositol phosphate signaling, which is involved in diverse cellular processes such as cell growth, vesicular trafficking, and ion channel regulation. The conversion of InsP6 to InsP7/PP-InsP5 and InsP5 to PP-InsP4 highlights the significance of IP6K1/IHPK1 in modulating inositol phosphate levels, thereby influencing various cellular functions (
Verified Bioactivity
The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
Technical Parameters
-
Species Human
-
Source Sf9 insect cells
-
Tag N-His;N-GST
-
Accession
Q92551 (M1-Q441)
-
Molecular Construction
-
N-term
-
His-GST
-
IP6K1 (M1-Q441)
Accession # Q92551 -
C-term
-
-
Protein Length
Full Length
-
Synonyms
IP6K1; ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase; Prev. IHPK1; Pi Uptake Stimulator; Inositol Hexaphosphate Kinase 1; Kinase; KIAA0263; PiUS; InsP6 Kinase 1; Inositol Hexakisphosphate Kinase 1; Alternative Protein IP6K1
-
AA Sequence
MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
-
Predicted Molecular Mass
78 kDa
-
Molecular Weight
Approximately 88 kDa, based on SDS-PAGE under reducing conditions.
-
Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 10% glycerol, 0.5 mM GSH.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
