IP6K1/IHPK1 Protein, Human (sf9, His-GST)

IP6K1, also known as the IHPK1 protein, plays a crucial role in cell signaling by catalyzing the conversion of inositol hexaphosphate (InsP6) to inositol diphosphate pentaphosphate (InsP7/PP-InsP5). In addition, this enzyme is also involved in the conversion of 1,3,4,5,6-pentaphosphate (InsP5) to PP-InsP4. IP6K1/IHPK1 Protein, Human (sf9, His-GST) is the recombinant human-derived IP6K1/IHPK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

The IP6K1/IHPK1 protein is an enzyme that plays a crucial role in inositol phosphate metabolism. It converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5), representing a key step in the synthesis of higher inositol polyphosphates. Additionally, IP6K1/IHPK1 catalyzes the conversion of 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. These enzymatic activities contribute to the intricate regulation of inositol phosphate signaling, which is involved in diverse cellular processes such as cell growth, vesicular trafficking, and ion channel regulation. The conversion of InsP6 to InsP7/PP-InsP5 and InsP5 to PP-InsP4 highlights the significance of IP6K1/IHPK1 in modulating inositol phosphate levels, thereby influencing various cellular functions (

Human

Sf9 insect cells

N-His;N-GST

Q92551 (M1-Q441)

9807  [NCBI]

Full Length

MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ

Approximately 88 kDa,based on SDS-PAGE under reducing conditions.

≥ 85%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.