IP6K1 - inositol hexakisphosphate kinase 1 Gene

Also Known as PiUS; IHPK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9807

About IP6K1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,724,294-49,786,542 (from NCBI)

This gene has 9 transcripts (splice variants), 218 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 17.4), testis (RPKM 16.8) and 25 other tissues.

Summary

This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

IP6K1 Products (3)

mRNA Protein Name
NM_001006115.3 NP_001006115.1 inositol hexakisphosphate kinase 1 isoform 2
NM_001242829.2 NP_001229758.1 inositol hexakisphosphate kinase 1 isoform 1
NM_153273.4 NP_695005.1 inositol hexakisphosphate kinase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables inositol hexakisphosphate kinase activity IDA
IDA: Inferred from direct assay
10574768 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
10574768 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IP6K1 Protein Structure

IPK

IPK: Inositol polyphosphate kinase (207 - 434)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

inositol hexakisphosphate kinase 1

  • ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IP6K1 Q92551 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
IP6K1 Q92551 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
IP6K1 Q92551 UBE4A Homo sapiens Q14139
Y2H Array
32296183
Intra
IP6K1 Q92551 UBE4A Homo sapiens Q14139
Y2H Prey Pooling
32296183
Intra
IP6K1 Q92551 RPL11 Homo sapiens P62913-2
Y2H Prey Pooling
32296183
Intra
IP6K1 Q92551 RPL11 Homo sapiens P62913-2
Y2H Array
32296183
Intra
IP6K1 Q92551 VIM Homo sapiens P08670
Y2H Array
32296183
Intra
IP6K1 Q92551 VIM Homo sapiens P08670
Y2H Prey Pooling
32296183
Intra
IP6K1 Q92551 EXOSC7 Homo sapiens Q15024
Y2H Array
32296183
Intra
IP6K1 Q92551 EXOSC7 Homo sapiens Q15024
Y2H Pooling
16189514
Intra
IP6K1 Q92551 EXOSC7 Homo sapiens Q15024
Y2H Prey Pooling
32296183
Intra
IP6K1 Q92551 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
IP6K1 Q92551 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
IP6K1 Q92551 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IP6K1 Proteins

Cat. No. Product Name Accession Purity
HY-P77427 IP6K1/IHPK1 Protein, Human (sf9, His-GST) Q92551 (M1-Q441) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150607 UNC7467 Inhibitor 99.87% Unkown
HY-110079 TNP Inhibitor 98.04% Unkown
HY-153530 LI-2242 Inhibitor 98.95% Unkown
HY-171099 SC-919 Inhibitor 98.68% Unkown
HY-122706A IP6K2-IN-2 Inhibitor 99.70% Unkown
HY-161032 IP6K2-IN-1 Inhibitor 99.47% Unkown
HY-185141 IP6K-IN-2 Inhibitor / Unkown
HY-RS06861 IP6K1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19698 Ip6k1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26193 Ip6k1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IP6K1 VGNC VGNC:30237
Rattus norvegicus IP6K1 RGD RGD:71025
Felis catus IP6K1 VGNC VGNC:62951
Macaca mulatta IP6K1 VGNC VGNC:73621
Canis familiaris IP6K1 VGNC VGNC:42061
Mus musculus IP6K1 MGD MGI:1351633
Others IP6K1 NCBI