MEPE/OF45 Protein, Mouse (HEK293, His)
MEPE/OF45 Protein, pivotal in regulating renal phosphate and uric acid excretion, influences bone mineralization in osteoblasts and chondrocytes, with notable effects on craniofacial structures. Its role in dental pulp stem cell proliferation is significant. MEPE/OF45's interaction with PHEX, mediated by its ASARM motif, is zinc-dependent, adding complexity to its regulatory functions. MEPE/OF45 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MEPE/OF45 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
MEPE/OF45 Protein, pivotal in regulating renal phosphate and uric acid excretion, influences bone mineralization in osteoblasts and chondrocytes, with notable effects on craniofacial structures. Its role in dental pulp stem cell proliferation is significant. MEPE/OF45's interaction with PHEX, mediated by its ASARM motif, is zinc-dependent, adding complexity to its regulatory functions. MEPE/OF45 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MEPE/OF45 protein, expressed by HEK293 , with C-His labeled tag.
Background
MEPE/OF45 protein plays a pivotal role in the regulation of renal phosphate and uric acid excretion. Its influence extends to the intricate processes of bone mineralization, affecting both osteoblasts and chondrocytes. MEPE/OF45's impact on the mineralization of the extracellular matrix is particularly notable in craniofacial structures, including teeth, bone, and cartilage. Moreover, it contributes to the proliferation of dental pulp stem cells. The protein's interaction with PHEX, mediated by its ASARM motif, is contingent on zinc, adding a layer of complexity to its regulatory functions.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
Q8K4L6 (A25-D441)
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Molecular Construction
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N-term
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MEPE (A25-D441)
Accession # Q8K4L6 -
8*His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
MEPE; Osteoblast/Osteocyte Factor 45; Matrix Extracellular Phosphoglycoprotein; Osteoregulin; Matrix, Extracellular Phosphoglycoprotein With ASARM Motif (Bone); OF45
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AA Sequence
APMPNEDRSSCGNQDSIHKDLAASVYPDPTVDEGTEDGQGALLHPPGQDRYGAALLRNITQPVKSLVTGAELRREGNQEKRPQSVLSVIPADVNDAKVSLKDIKNQESYLLTQSSPVKSKHTKHTRQTRRSTHYLTHLPQIKKTPSDLEGSGSPDLLVRGDNDVPPFSGDGQHFMHIPGKGGAGSGPESSTSRPLSGSSKAEVIDPHMSGLGSNEIPGREGHGGSAYATRDKAAQGAGSAGGSLVGGSNEITGSTNFRELPGKEGNRINAGSQNAHQGKVEFHYPQVASREKVKGGVEHAGRAGYNEIPKSSKGSSSKDAEESKGNQLTLTASQRFPGKGKSQGPALPSHSLSNEVKSEENHYVFHGQNNLTPNKGMSQRRGSWPSRRPNSHRRASTRQRDSSESSSSGSSSESHGD
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Predicted Molecular Mass
45.3 kDa
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Molecular Weight
Approximately 45-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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