MIP-3 alpha/CCL20 Protein, Bovine (His-SUMO)

MIP-3 alpha/CCL20 Protein serves as a ligand for C-C chemokine receptor CCR6, initiating a potent chemotactic response and mobilizing intracellular calcium ions upon CCR6 binding and activation. The CCL20-CCR6 ligand-receptor pair plays a crucial role in chemotaxis, attracting dendritic cells (DC), effector/memory T-cells, and B-cells. This partnership is particularly significant in skin and mucosal surfaces under various conditions, including homeostasis, inflammation, cancer, and autoimmune diseases. Acting as a chemotactic factor, CCL20 specifically attracts lymphocytes and, to a lesser extent, neutrophils, excluding monocytes. Furthermore, it is involved in recruiting both pro-inflammatory IL17-producing helper T-cells (Th17) and regulatory T-cells (Treg) to inflammation sites. CCL20 is essential for the optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Additionally, it positively regulates sperm motility and chemotaxis by binding to CCR6, triggering Ca2+ mobilization in sperm, a crucial factor for motility. CCL20 may also contribute to the formation and function of mucosal lymphoid tissues by directing lymphocytes and dendritic cells towards epithelial cells.