Monoglyceride lipase Protein, Rat (P.pastoris, His)
Monoglyceride lipase is a key enzyme in lipid metabolism and plays a key role in converting monoacylglycerols into free fatty acids and glycerol, contributing to important cellular processes. In addition to being involved in lipid metabolism, this enzyme also hydrolyzes the endocannabinoid 2-arachidonoylglycerol, thereby affecting the complex regulation of endocannabinoid signaling, nociception, and pain perception. Monoglyceride lipase Protein, Rat (P.pastoris, His) is the recombinant rat-derived Monoglyceride lipase protein, expressed by P. pastoris , with N-His labeled tag.
- Species: Rat
- Source: P. pastoris
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Monoglyceride lipase is a key enzyme in lipid metabolism and plays a key role in converting monoacylglycerols into free fatty acids and glycerol, contributing to important cellular processes. In addition to being involved in lipid metabolism, this enzyme also hydrolyzes the endocannabinoid 2-arachidonoylglycerol, thereby affecting the complex regulation of endocannabinoid signaling, nociception, and pain perception. Monoglyceride lipase Protein, Rat (P.pastoris, His) is the recombinant rat-derived Monoglyceride lipase protein, expressed by P. pastoris , with N-His labeled tag.
Background
Monoglyceride lipase (MGLL) is a pivotal enzyme with diverse functions in lipid metabolism and signaling pathways. It plays a central role in converting monoacylglycerides into free fatty acids and glycerol. Additionally, MGLL is involved in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol, contributing to the regulation of endocannabinoid signaling and influencing nociperception and pain perception. Beyond its role in lipid metabolism, MGLL is implicated in the modulation of fatty acid levels, acting as signaling molecules that facilitate cancer cell migration, invasion, and tumor growth (By similarity). The multifunctional nature of Monoglyceride lipase underscores its importance in various physiological processes, including lipid homeostasis, pain regulation, and potential implications in cancer progression.
Technical Parameters
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Species Rat
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Source P. pastoris
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Tag N-His
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Accession
Q8R431 (M1-P303)
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Molecular Construction
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N-term
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His
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Mgll (M1-P303)
Accession # Q8R431 -
C-term
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Protein Length
Full Length
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Synonyms
MGLL; MGL; Monoglyceride Lipase; Lysophospholipase Homolog; Monoacylglycerol Lipase; Lysophospholipase-Like; HU-K5; HUK5; MAGL
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AA Sequence
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
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Predicted Molecular Mass
34.8 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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