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  6. PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi)

PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi)

Cat. No.: HY-P78193
Handling Instructions

PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is 501 a.a., with molecular weight of 70-83 kDa.

For research use only. We do not sell to patients.

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Description

PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is 501 a.a., with molecular weight of 70-83 kDa.

Background

PDGF R alpha, a tyrosine-protein kinase, assumes a pivotal role as a cell-surface receptor for PDGFA, PDGFB, and PDGFC, exerting significant influence over embryonic development, cell proliferation, survival, and chemotaxis. Its impact on cell behavior varies, as it can either promote or inhibit cell proliferation and migration based on contextual cues. The receptor's indispensable role extends to the differentiation of bone marrow-derived mesenchymal stem cells and is critical for normal skeletal development, embryonic cephalic closure, and the formation of the gastrointestinal mucosa. Moreover, PDGF R alpha contributes to the recruitment of mesenchymal cells and the development of intestinal villi. It plays a crucial role in wound healing by influencing cell migration and chemotaxis. PDGF R alpha's engagement with its ligands activates diverse signaling cascades, modulated by ligand specificity and influenced by heterodimer formation between PDGFRA and PDGFRB. The receptor phosphorylates key targets such as PIK3R1, PLCG1, and PTPN11, triggering downstream events like the AKT1 signaling pathway activation and induction of MAP kinase and STAT family members. The dynamic regulation of PDGF R alpha signaling involves the interplay of protein phosphatases and rapid internalization of the activated receptor to finely tune its cellular responses.

Species

Human

Source

HEK293

Tag

C-Avi;C-His

Accession

P16234 (Q24-E524)

Gene ID
Molecular Construction
N-term
PDGF R alpha (Q24-E524)
Accession # P16234
His-Avi
C-term
Synonyms
PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2
Molecular Weight

70-83 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi)
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HY-P78193
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