RNF113A Protein, Human
RNF113A is an important spliceosome component that participates in pre-mRNA splicing and contributes to U12-type intron splicing within the small spliceosome. As an E3 ubiquitin protein ligase, it catalyzes the transfer of ubiquitin to target proteins. RNF113A Protein, Human is the recombinant human-derived RNF113A protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
RNF113A is an important spliceosome component that participates in pre-mRNA splicing and contributes to U12-type intron splicing within the small spliceosome. As an E3 ubiquitin protein ligase, it catalyzes the transfer of ubiquitin to target proteins. RNF113A Protein, Human is the recombinant human-derived RNF113A protein, expressed by E. coli , with tag free.
RNF113A serves as a vital component of the spliceosome, participating in pre-mRNA splicing processes and contributing to the splicing of U12-type introns as a component of the minor spliceosome. Additionally, RNF113A functions as an E3 ubiquitin-protein ligase, catalyzing the transfer of ubiquitin onto target proteins. Notably, it catalyzes the polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. This multifaceted protein plays a crucial role in DNA repair by synthesizing 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage induced by alkylating agents. Furthermore, RNF113A regulates signaling termination by ubiquitinating CXCR4, leading to its degradation and, consequently, the cessation of CXCR4 signaling.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
O15541 (A2-T343)
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Gene ID7737
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Molecular Construction
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N-term
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RNF113A (A2-T343)
Accession # O15541 -
C-term
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Protein Length
Full Length
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Synonyms
RNF113A; E3 ubiquitin-protein ligase RNF113A; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183
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AA Sequence
AEQLSPGKAVDQVCTFLFKKPGRKGAAGRRKRPACDPEPGESGSSSDEGCTVVRPEKKRVTHNPMIQKTRDSGKQKAAYGDLSSEEEEENEPESLGVVYKSTRSAKPVGPEDMGATAVYELDTEKERDAQAIFERSQKIQEELRGKEDDKIYRGINNYQKYMKPKDTSMGNASSGMVRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQIERELDEGRYGVYEDENYEVGSDDEEIPFKCFICRQSFQNPVVTKCRHYFCESCALQHFRTTPRCYVCDQQTNGVFNPAKELIAKLEKHRATGEGGASDLPEDPDEDAIPIT
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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