ST2/IL1RL1 Protein, Cynomolgus (HEK293, His)

ST2/IL1RL1 Protein is a member of the toll-like receptor superfamily, but unlike other members, it does not induce inflammatory responses by activating NF-κB, although it can activate MAP kinase. ST2/IL1RL1 Protein exists in two forms (soluble and membrane-bound forms). When the heart muscle is stretched, the ST2 gene is upregulated, and the circulating soluble ST2/IL1RL1 Protein concentration rapidly increases. Its membrane-bound form serves as a receptor for IL-33, which binds to IL-33 to regulate cardiac diseases and injuries, such as ischemic events, triggering a cardioprotective effect and maintaining cardiac function. The membrane-bound form of ST2/IL1RL1 Protein negatively regulates the signaling transduction of type I interleukin 1 receptor (IL-1RI) and toll-like receptor 4 (TLR4) by sequestering the adaptor MyD88 and Mal. It can maintain endotoxin tolerance^[1][2].
Overexpression of ST2/IL1RL1 Protein increases the production of neutrophil chemokine IL-8 and enhances HRV1B-induced IP-10 (a chemokine involved in exacerbation of asthma). ST2/IL1RL1 Protein also promotes proinflammatory responses to airway bacterial and viral infections. Therefore, ST2/IL1RL1 Protein plays an important role in inflammation regulation^[3].