STK16 Protein, Human (GST)

The STK16 protein is a membrane-associated kinase that phosphorylates serine and threonine residues on various substrates such as DRG1, ENO1, and EIF4EBP1, suggesting multiple cellular involvement. Autophosphorylation contributes to its regulatory function. STK16 Protein, Human (GST) is the recombinant human-derived STK16 protein, expressed by E. coli , with N-GST labeled tag.

STK16 Protein, a membrane-associated kinase, exhibits phosphorylation activity on serine and threonine residues. In vitro, it phosphorylates various substrates, including DRG1, ENO1, and EIF4EBP1, indicating its potential involvement in diverse cellular processes. The protein is also known to autophosphorylate, further contributing to its regulatory functions. While its precise role in secretory vesicle trafficking or intracellular signaling remains to be fully elucidated, STK16 may play a part in modulating stromal-epithelial interactions during ductal morphogenesis in the mammary gland. Additionally, there is a suggestion of its involvement in TGF-beta signaling. Notably, STK16 demonstrates the ability to autophosphorylate on a tyrosine residue, although its significance in tyrosine-protein kinase activity toward other proteins remains unclear.

Human

E. coli

N-GST

O75716 (M1-I305)

8576  [NCBI]

Full Length

MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI

Approximately 50-55 kDa, based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.