STK16 Protein, Human (GST)
The STK16 protein is a membrane-associated kinase that phosphorylates serine and threonine residues on various substrates such as DRG1, ENO1, and EIF4EBP1, suggesting multiple cellular involvement. Autophosphorylation contributes to its regulatory function. STK16 Protein, Human (GST) is the recombinant human-derived STK16 protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The STK16 protein is a membrane-associated kinase that phosphorylates serine and threonine residues on various substrates such as DRG1, ENO1, and EIF4EBP1, suggesting multiple cellular involvement. Autophosphorylation contributes to its regulatory function. STK16 Protein, Human (GST) is the recombinant human-derived STK16 protein, expressed by E. coli , with N-GST labeled tag.
Background
STK16 Protein, a membrane-associated kinase, exhibits phosphorylation activity on serine and threonine residues. In vitro, it phosphorylates various substrates, including DRG1, ENO1, and EIF4EBP1, indicating its potential involvement in diverse cellular processes. The protein is also known to autophosphorylate, further contributing to its regulatory functions. While its precise role in secretory vesicle trafficking or intracellular signaling remains to be fully elucidated, STK16 may play a part in modulating stromal-epithelial interactions during ductal morphogenesis in the mammary gland. Additionally, there is a suggestion of its involvement in TGF-beta signaling. Notably, STK16 demonstrates the ability to autophosphorylate on a tyrosine residue, although its significance in tyrosine-protein kinase activity toward other proteins remains unclear.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
O75716 (M1-I305)
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Molecular Construction
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N-term
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GST
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STK16 (M1-I305)
Accession # O75716 -
C-term
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Protein Length
Full Length
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Synonyms
STK16; TSF1; Serine/Threonine Kinase 16; HPSK; PKL12; Protein Kinase Expressed In Day 12 Fetal Liver; MPSK; Non-Specific Serine/Threonine Protein Kinase; Myristoylated And Palmitoylated Serine/Threonine-Protein Kinase; TSF-1; Serine/Threonine-Protein Kina
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AA Sequence
MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI
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Predicted Molecular Mass
61.5 kDa
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Molecular Weight
Approximately 50-55 kDa, based on SDS-PAGE under reducing conditions.
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Structure/Form
Monomer
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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