STK16 - serine/threonine kinase 16 Gene

Also Known as PSK; KRCT; MPSK; TSF1; hPSK; PKL12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8576

About STK16

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,245,479-219,250,337 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.6), brain (RPKM 6.9) and 25 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

STK16 Products (4)

mRNA Protein Name
NM_001008910.4 NP_001008910.1 serine/threonine-protein kinase 16 isoform 1
NM_001330213.2 NP_001317142.1 serine/threonine-protein kinase 16 isoform 1
NM_001330214.1 NP_001317143.1 serine/threonine-protein kinase 16 isoform 2
NM_001330215.2 NP_001317144.1 serine/threonine-protein kinase 16 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
18184589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK16 Protein Structure

Pkinase

Pkinase: Protein kinase domain (22 - 287)

  • 0
  • 100
  • 200
  • 305 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 16

  • TGF-beta-stimulated factor 1

STK16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STK16 O75716 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
STK16 O75716 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
STK16 O75716 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
STK16 O75716 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
STK16 O75716 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
STK16 O75716 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra
STK16 O75716 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
STK16 O75716 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
STK16 O75716 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
STK16 O75716 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
STK16 O75716 KCTD14 Homo sapiens Q9BQ13
Validated Y2H
25416956
Intra
STK16 O75716 KCTD14 Homo sapiens Q9BQ13
Y2H Array
25416956
Intra
STK16 O75716 KCTD14 Homo sapiens Q9BQ13
Y2H Array
29892012
Intra
STK16 O75716 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra
STK16 O75716 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
STK16 O75716 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
STK16 O75716 ZNF343 Homo sapiens Q6P1L6
Y2H Prey Pooling
32296183
Intra
STK16 O75716 ZNF343 Homo sapiens Q6P1L6
Y2H Array
32296183
Intra
STK16 O75716 ZNF343 Homo sapiens Q6P1L6
Validated Y2H
32296183
Intra
STK16 O75716 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
STK16 O75716 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
STK16 O75716 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KLHL20 Homo sapiens Q9BS75
Validated Y2H
32296183
Intra
STK16 O75716 KLHL20 Homo sapiens Q9BS75
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KLHL20 Homo sapiens Q9BS75
Y2H Array
32296183
Intra
STK16 O75716 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
STK16 O75716 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
STK16 O75716 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
STK16 O75716 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
STK16 O75716 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
STK16 O75716 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
STK16 O75716 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
STK16 O75716 FXR1 Homo sapiens P51114-2
Validated Y2H
32296183
Intra
STK16 O75716 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra
STK16 O75716 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra
STK16 O75716 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra
STK16 O75716 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
STK16 O75716 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
STK16 O75716 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
Intra
STK16 O75716 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
STK16 O75716 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
STK16 O75716 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
STK16 O75716 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra
STK16 O75716 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
STK16 O75716 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
STK16 O75716 NAA80 Homo sapiens Q93015-2
Validated Y2H
32296183
Intra
STK16 O75716 MIER3 Homo sapiens Q7Z3K6-2
Y2H Prey Pooling
32296183
Intra
STK16 O75716 MIER3 Homo sapiens Q7Z3K6-2
Validated Y2H
32296183
Intra
STK16 O75716 MIER3 Homo sapiens Q7Z3K6-2
Y2H Array
32296183
Intra
STK16 O75716 KCTD14 Homo sapiens Q9BQ13-2
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KCTD14 Homo sapiens Q9BQ13-2
Validated Y2H
32296183
Intra
STK16 O75716 KCTD14 Homo sapiens Q9BQ13-2
Y2H Array
32296183
Intra
STK16 O75716 ATP23 Homo sapiens Q9Y6H3
Y2H Prey Pooling
32296183
Intra
STK16 O75716 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32296183
Intra
STK16 O75716 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32296183
Intra
STK16 O75716 RSPO4 Homo sapiens Q2I0M5
Validated Y2H
32296183
Intra
STK16 O75716 RSPO4 Homo sapiens Q2I0M5
Y2H Prey Pooling
32296183
Intra
STK16 O75716 RSPO4 Homo sapiens Q2I0M5
Y2H Array
32296183
Intra
STK16 O75716 BHLHA9 Homo sapiens Q7RTU4
Y2H Prey Pooling
32296183
Intra
STK16 O75716 BHLHA9 Homo sapiens Q7RTU4
Validated Y2H
32296183
Intra
STK16 O75716 BHLHA9 Homo sapiens Q7RTU4
Y2H Array
32296183
Intra
STK16 O75716 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
STK16 O75716 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra
STK16 O75716 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
STK16 O75716 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
STK16 O75716 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
STK16 O75716 EFHC2 Homo sapiens Q5JST6
Y2H Array
25416956
Intra
STK16 O75716 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
25416956
Intra
STK16 O75716 TNFAIP1 Homo sapiens Q13829
Y2H Array
25416956
Intra
STK16 O75716 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra
STK16 O75716 PKNOX2 Homo sapiens Q96KN3
Validated Y2H
32296183
Intra
STK16 O75716 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra
STK16 O75716 MIIP Homo sapiens Q5JXC2
Y2H Array
31515488
Intra
STK16 O75716 MIIP Homo sapiens Q5JXC2
Validated Y2H
25416956
Intra
STK16 O75716 MIIP Homo sapiens Q5JXC2
Y2H Array
25416956
Intra
STK16 O75716 PRKAR1B Homo sapiens P31321
Validated Y2H
32296183
Intra
STK16 O75716 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
STK16 O75716 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
STK16 O75716 PTH1R Homo sapiens Q03431
Y2H Array
32296183
Intra
STK16 O75716 PTH1R Homo sapiens Q03431
Y2H Prey Pooling
32296183
Intra
STK16 O75716 PTH1R Homo sapiens Q03431
Validated Y2H
32296183
Intra
STK16 O75716 SKIL Homo sapiens P12757
Y2H Prey Pooling
25416956
Intra
STK16 O75716 SKIL Homo sapiens P12757
Validated Y2H
25416956
Intra
STK16 O75716 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
STK16 O75716 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
STK16 O75716 ZNF330 Homo sapiens Q9Y3S2
Y2H Array
32296183
Intra
STK16 O75716 ZNF330 Homo sapiens Q9Y3S2
Y2H Prey Pooling
32296183
Intra
STK16 O75716 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
Intra
STK16 O75716 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
STK16 O75716 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
STK16 O75716 DNAJA3 Homo sapiens Q96EY1-2
Y2H Prey Pooling
25416956
Intra
STK16 O75716 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
32296183
Intra
STK16 O75716 SAXO1 Homo sapiens Q8IYX7
Y2H Array
32296183
Intra
STK16 O75716 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
32296183
Intra
STK16 O75716 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
32296183
Intra
STK16 O75716 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra
STK16 O75716 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra
STK16 O75716 SOCS2 Homo sapiens O14508
Y2H Prey Pooling
32296183
Intra
STK16 O75716 SOCS2 Homo sapiens O14508
Y2H Array
32296183
Intra
STK16 O75716 GABPA Homo sapiens Q06546
Validated Y2H
32296183
Cross
STK16 O75716 tir Escherichia coli O157:H7 Q7DB77
Lumier
25519916
Intra
STK16 O75716 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
STK16 O75716 INCA1 Homo sapiens Q0VD86
Validated Y2H
25416956
Intra
STK16 O75716 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
STK16 O75716 INCA1 Homo sapiens Q0VD86
Y2H Array
25416956
Intra
STK16 O75716 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
STK16 O75716 AGR2 Homo sapiens O95994
Validated Y2H
32296183
Intra
STK16 O75716 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
STK16 O75716 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
STK16 O75716 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
STK16 O75716 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
STK16 O75716 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
STK16 O75716 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
STK16 O75716 DRG1 Homo sapiens Q9Y295
Y2H Array
25416956
Intra
STK16 O75716 DRG1 Homo sapiens Q9Y295
Validated Y2H
25416956
Intra
STK16 O75716 TCF12 Homo sapiens Q99081
Validated Y2H
25416956
Intra
STK16 O75716 FRS3 Homo sapiens O43559
Y2H Array
32296183
Intra
STK16 O75716 FRS3 Homo sapiens O43559
Y2H Prey Pooling
32296183
Intra
STK16 O75716 PLA2G10 Homo sapiens O15496
Y2H Array
32296183
Intra
STK16 O75716 PLA2G10 Homo sapiens O15496
Y2H Prey Pooling
32296183
Intra
STK16 O75716 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra
STK16 O75716 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
STK16 O75716 PLSCR1 Homo sapiens O15162
Y2H Prey Pooling
25416956
Intra
STK16 O75716 ADAMTSL4 Homo sapiens Q6UY14
Y2H Array
19060904
Intra
STK16 O75716 ADAMTSL4 Homo sapiens Q6UY14
Y2H Pooling
19060904
Intra
STK16 O75716 ADAMTSL4 Homo sapiens Q6UY14
Y2H Pooling
16189514
Intra
STK16 O75716 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
STK16 O75716 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
STK16 O75716 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
STK16 O75716 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra
STK16 O75716 SPRY2 Homo sapiens O43597
Y2H Prey Pooling
25416956
Intra
STK16 O75716 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra
STK16 O75716 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
STK16 O75716 EFEMP2 Homo sapiens O95967
Validated Y2H
32296183
Intra
STK16 O75716 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra
STK16 O75716 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra
STK16 O75716 EFEMP2 Homo sapiens O95967
Y2H Array
25416956
Intra
STK16 O75716 KCTD17 Homo sapiens Q8N5Z5
Y2H Prey Pooling
25416956
Intra
STK16 O75716 KCTD17 Homo sapiens Q8N5Z5
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KCTD17 Homo sapiens Q8N5Z5
Validated Y2H
32296183
Intra
STK16 O75716 KCTD17 Homo sapiens Q8N5Z5
Y2H Array
32296183
Intra
STK16 O75716 KCTD17 Homo sapiens Q8N5Z5
Y2H Pooling
16189514
Intra
STK16 O75716 RPIA Homo sapiens P49247
Validated Y2H
25416956
Intra
STK16 O75716 RPIA Homo sapiens P49247
Y2H Pooling
16189514
Intra
STK16 O75716 RFX6 Homo sapiens Q8HWS3
Validated Y2H
25416956
Intra
STK16 O75716 RFX6 Homo sapiens Q8HWS3
Y2H Array
25416956
Intra
STK16 O75716 IKZF3 Homo sapiens Q9UKT9
Y2H Array
25416956
Intra
STK16 O75716 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
STK16 O75716 CRX Homo sapiens O43186
Y2H Array
25416956
Intra
STK16 O75716 CRX Homo sapiens O43186
Y2H Prey Pooling
25416956
Intra
STK16 O75716 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
STK16 O75716 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
STK16 O75716 PLSCR3 Homo sapiens Q9NRY6
Y2H Prey Pooling
25416956
Intra
STK16 O75716 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
25416956
Intra
STK16 O75716 PLSCR3 Homo sapiens Q9NRY6
Y2H Prey Pooling
32296183
Intra
STK16 O75716 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra
STK16 O75716 PLSCR3 Homo sapiens Q9NRY6
Y2H Array
32296183
Intra
STK16 O75716 PCSK5 Homo sapiens Q92824
Y2H Prey Pooling
25416956
Intra
STK16 O75716 ARNT2 Homo sapiens Q9HBZ2
Y2H Prey Pooling
32296183
Intra
STK16 O75716 ARNT2 Homo sapiens Q9HBZ2
Y2H Array
32296183
Intra
STK16 O75716 CBX3 Homo sapiens Q13185
Y2H Prey Pooling
32296183
Intra
STK16 O75716 CBX3 Homo sapiens Q13185
Validated Y2H
32296183
Intra
STK16 O75716 CBX3 Homo sapiens Q13185
Y2H Array
32296183
Cross
STK16 O75716 Drg1 Mus musculus P32233
Y2H
18184589
Cross
STK16 O75716 Drg1 Mus musculus P32233
Pull Down
18184589
Cross
STK16 O75716 Drg1 Mus musculus P32233
Protein Kinase Assay
18184589
Cross
STK16 O75716 Drg1 Mus musculus P32233
Anti Bait CoIP
18184589
Intra
STK16 O75716 CFP Homo sapiens P27918
Y2H Array
32296183
Intra
STK16 O75716 CFP Homo sapiens P27918
Y2H Prey Pooling
32296183
Intra
STK16 O75716 CFP Homo sapiens P27918
Validated Y2H
32296183
Intra
STK16 O75716 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
STK16 O75716 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
STK16 O75716 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
STK16 O75716 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK16 Proteins

Cat. No. Product Name Accession Purity
HY-P76097 STK16 Protein, Human (GST) O75716 (M1-I305) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Diffuse Mesangial Sclerosis

  • Familial Mesangial Sclerosis

  • Mesangial Sclerosis, Diffuse

  • Dms

  • Diffuse Isolated Mesangial Sclerosis

  • Isolated Diffuse Mesangial Sclerosis

  • Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101270 STK16-IN-1 Inhibitor 99.81% Unkown
HY-19353 SR7826 Inhibitor 99.30% Unkown
HY-181293 PROTAC AAK1 degrader-1 Degrader / Unkown
HY-RS13923 STK16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18549 Stk16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25031 Stk16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STK16 VGNC VGNC:65776
Mus musculus STK16 MGD MGI:1313271
Rattus norvegicus STK16 RGD RGD:629474
Canis familiaris STK16 VGNC VGNC:46906
Bos taurus STK16 VGNC VGNC:35387
Macaca mulatta STK16 VGNC VGNC:77912
Others STK16 NCBI