Syntaxin-6 Protein, Human

Syntaxin-6, a SNARE protein, actively facilitates the movement of transport vesicles to their target membranes. Its role extends to targeting endosomes to the trans-Golgi network, suggesting involvement in retrograde trafficking. In collaboration with SNARE STX12, Syntaxin-6 promotes the movement of vesicles from endosomes to the cell membrane, implicating its function in the endocytic recycling pathway. Within a complex containing STX6, STX12, VAMP4, and VTI1A, Syntaxin-6 is identified, emphasizing its participation in intricate cellular processes. Furthermore, it binds EEA1 and interacts with VPS45A, suggesting additional layers of molecular regulation. Syntaxin-6 also interfaces with MARCHF2, promoting MARCHF2-mediated ubiquitination and degradation of CFTR. Interactions with MARCHF3, GOPC, BLTP3B, BAIAP3 (with increased affinity in the presence of calcium), and VPS13B further underscore the diverse molecular associations governing Syntaxin-6's multifaceted cellular functions.