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Syntaxin-6 Protein, Human

Cat. No.: HY-P71032
Handling Instructions

Syntaxin-6 is a SNARE protein that actively promotes vesicle movement to target membranes. Its involvement in retrograde transport is evident because it targets endosomes to the trans-Golgi network. Syntaxin-6 Protein, Human is the recombinant human-derived Syntaxin-6 protein, expressed by E. coli , with tag free. The total length of Syntaxin-6 Protein, Human is 233 a.a., with molecular weight of ~32.0 kDa.

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Description

Syntaxin-6 is a SNARE protein that actively promotes vesicle movement to target membranes. Its involvement in retrograde transport is evident because it targets endosomes to the trans-Golgi network. Syntaxin-6 Protein, Human is the recombinant human-derived Syntaxin-6 protein, expressed by E. coli , with tag free. The total length of Syntaxin-6 Protein, Human is 233 a.a., with molecular weight of ~32.0 kDa.

Background

Syntaxin-6, a SNARE protein, actively facilitates the movement of transport vesicles to their target membranes. Its role extends to targeting endosomes to the trans-Golgi network, suggesting involvement in retrograde trafficking. In collaboration with SNARE STX12, Syntaxin-6 promotes the movement of vesicles from endosomes to the cell membrane, implicating its function in the endocytic recycling pathway. Within a complex containing STX6, STX12, VAMP4, and VTI1A, Syntaxin-6 is identified, emphasizing its participation in intricate cellular processes. Furthermore, it binds EEA1 and interacts with VPS45A, suggesting additional layers of molecular regulation. Syntaxin-6 also interfaces with MARCHF2, promoting MARCHF2-mediated ubiquitination and degradation of CFTR. Interactions with MARCHF3, GOPC, BLTP3B, BAIAP3 (with increased affinity in the presence of calcium), and VPS13B further underscore the diverse molecular associations governing Syntaxin-6's multifaceted cellular functions.

Species

Human

Source

E. coli

Tag

Tag Free

Accession

O43752 (S2-Q234)

Gene ID
Synonyms
Syntaxin-6; STX6
AA Sequence

SMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQ

Molecular Weight

Approximately 32.0 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Syntaxin-6 Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Syntaxin-6 Protein, Human
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HY-P71032
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