Syntaxin-6 Protein, Human
Syntaxin-6 is a SNARE protein that actively promotes vesicle movement to target membranes. Its involvement in retrograde transport is evident because it targets endosomes to the trans-Golgi network. Syntaxin-6 Protein, Human is the recombinant human-derived Syntaxin-6 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Stockage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Activité biologique
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Technical Parameters
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Product Properties
- Documentation
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Activité biologique
Description
Syntaxin-6 is a SNARE protein that actively promotes vesicle movement to target membranes. Its involvement in retrograde transport is evident because it targets endosomes to the trans-Golgi network. Syntaxin-6 Protein, Human is the recombinant human-derived Syntaxin-6 protein, expressed by E. coli , with tag free.
Background
Syntaxin-6, a SNARE protein, actively facilitates the movement of transport vesicles to their target membranes. Its role extends to targeting endosomes to the trans-Golgi network, suggesting involvement in retrograde trafficking. In collaboration with SNARE STX12, Syntaxin-6 promotes the movement of vesicles from endosomes to the cell membrane, implicating its function in the endocytic recycling pathway. Within a complex containing STX6, STX12, VAMP4, and VTI1A, Syntaxin-6 is identified, emphasizing its participation in intricate cellular processes. Furthermore, it binds EEA1 and interacts with VPS45A, suggesting additional layers of molecular regulation. Syntaxin-6 also interfaces with MARCHF2, promoting MARCHF2-mediated ubiquitination and degradation of CFTR. Interactions with MARCHF3, GOPC, BLTP3B, BAIAP3 (with increased affinity in the presence of calcium), and VPS13B further underscore the diverse molecular associations governing Syntaxin-6's multifaceted cellular functions.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
O43752 (S2-Q234)
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Molecular Construction
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N-term
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Syntaxin-6 (S2-Q234)
Accession # O43752 -
C-term
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Protein Length
Cytoplasmic Domain
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Synonyms
STX6; Syntaxin-6; Syntaxin 6
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AA Sequence
SMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQ
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Predicted Molecular Mass
26.8 kDa
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Masse moléculaire
Approximately 32 kDa, based on SDS-PAGE under reducing conditions.
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Pureté
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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