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STX6 - syntaxin 6 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10228

About STX6

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:180,972,725-181,022,870 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 10.0), esophagus (RPKM 7.6) and 24 other tissues.

Summary

Enables syntaxin binding activity. Involved in several processes, including Golgi ribbon formation; retrograde transport, endosome to Golgi; and vesicle fusion. Acts upstream of or within endocytic recycling. Located in several cellular components, including early endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of SNARE complex. [provided by Alliance of Genome Resources, Apr 2022]

STX6 Products (2)

mRNA	Protein	Name
NM_001286210.2	NP_001273139.1	syntaxin-6 isoform 2
NM_005819.6	NP_005810.1	syntaxin-6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11384996	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	16154903	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within endocytic recycling	IMP IMP: Inferred from mutant phenotype	25799061	GOA
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	23677696	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	16154903	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	19224922	GOA
involved in vesicle fusion	IPI IPI: Inferred from physical interaction	10506127	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19224922	GOA
part of SNARE complex	IDA IDA: Inferred from direct assay	19620288	GOA
located in early endosome	IDA IDA: Inferred from direct assay	10506127	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10506127	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	16154903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX6 Protein Structure

Syntaxin-6_N

SNARE

0
100
200
255 a.a.

Protein Preferred Names	Protein Names
syntaxin-6

STX6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STX6	O43752	ARMC8	Homo sapiens	Q8IUR7-6	Validated Y2H	32296183
Intra	STX6	O43752	ARMC8	Homo sapiens	Q8IUR7-6	Y2H Array	32296183
Intra	STX6	O43752	ARMC8	Homo sapiens	Q8IUR7-6	Y2H Prey Pooling	32296183
Intra	STX6	O43752	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	STX6	O43752	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	STX6	O43752	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	STX6	O43752	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	STX6	O43752	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	STX6	O43752	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	STX6	O43752	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	STX6	O43752	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	STX6	O43752	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	STX6	O43752	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	STX6	O43752	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	STX6	O43752	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	STX6	O43752	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	STX6	O43752	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	STX6	O43752	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	STX6	O43752	MTERF2	Homo sapiens	Q49AM1	Y2H Prey Pooling	32296183
Intra	STX6	O43752	MTERF2	Homo sapiens	Q49AM1	Validated Y2H	32296183
Intra	STX6	O43752	MTERF2	Homo sapiens	Q49AM1	Y2H Array	32296183
Intra	STX6	O43752	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	STX6	O43752	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	STX6	O43752	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	STX6	O43752	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	STX6	O43752	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	STX6	O43752	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	STX6	O43752	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	STX6	O43752	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	STX6	O43752	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	STX6	O43752	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	STX6	O43752	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	STX6	O43752	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	STX6	O43752	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	STX6	O43752	NAPB	Homo sapiens	Q9H115	Y2H Array	25416956
Intra	STX6	O43752	NAPB	Homo sapiens	Q9H115	Anti Tag CoIP	33961781
Intra	STX6	O43752	NAPB	Homo sapiens	Q9H115	Y2H Prey Pooling	25416956
Intra	STX6	O43752	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	STX6	O43752	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	STX6	O43752	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	STX6	O43752	GOSR2	Homo sapiens	O14653	Validated Y2H	25416956
Intra	STX6	O43752	GOSR2	Homo sapiens	O14653	Y2H Array	25416956
Intra	STX6	O43752	GOSR2	Homo sapiens	O14653	Anti Tag CoIP	33961781
Intra	STX6	O43752	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	25419848
Intra	STX6	O43752	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	33422265
Intra	STX6	O43752	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	STX6	O43752	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	STX6	O43752	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	STX6	O43752	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	STX6	O43752	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	STX6	O43752	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	STX6	O43752	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	STX6	O43752	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
Intra	STX6	O43752	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	STX6	O43752	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	STX6	O43752	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	STX6	O43752	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	STX6	O43752	TMEM9	Homo sapiens	Q9P0T7	Y2H Prey Pooling	32296183
Intra	STX6	O43752	TMEM9	Homo sapiens	Q9P0T7	Validated Y2H	32296183
Intra	STX6	O43752	TMEM9	Homo sapiens	Q9P0T7	Y2H Array	32296183
Intra	STX6	O43752	STX4	Homo sapiens	Q12846	Anti Tag CoIP	33961781
Intra	STX6	O43752	STX4	Homo sapiens	Q12846	Anti Tag CoIP	28514442
Intra	STX6	O43752	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	STX6	O43752	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	STX6	O43752	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	STX6	O43752	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	STX6	O43752	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	STX6	O43752	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	STX6	O43752	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	STX6	O43752	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	STX6	O43752	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STX6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71032	Syntaxin-6 Protein, Human	O43752 (S2-Q234)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome	Cednik Syndrome CEDNIK Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Neurocutaneous Syndromes
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13986	STX6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20341	Stx6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26849	Stx6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STX6	VGNC	VGNC:78046
Felis catus	STX6	VGNC	VGNC:65816
Mus musculus	STX6	MGD	MGI:1926235
Rattus norvegicus	STX6	RGD	RGD:61915
Bos taurus	STX6	VGNC	VGNC:35442
Canis familiaris	STX6	VGNC	VGNC:55762
Others	STX6	NCBI