Tulp1 Protein, Human (His)
The Tulp1 protein is critical for normal development and function of photoreceptor synapses, affecting long-term survival. It interacts with cytoskeletal proteins and may be involved in protein transport within photoreceptor cells. Tulp1 Protein, Human (His) is the recombinant human-derived Tulp1 protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The Tulp1 protein is critical for normal development and function of photoreceptor synapses, affecting long-term survival. It interacts with cytoskeletal proteins and may be involved in protein transport within photoreceptor cells. Tulp1 Protein, Human (His) is the recombinant human-derived Tulp1 protein, expressed by E. coli , with N-His labeled tag.
Background
The Tulp1 Protein is essential for the normal development of photoreceptor synapses, and it is indispensable for both the normal function and long-term survival of photoreceptor cells. It interacts with cytoskeleton proteins, suggesting a potential role in protein transport within photoreceptor cells. Tulp1 also exhibits lipid-binding capabilities, with an affinity for various phosphatidylinositols and phosphatidic acid in vitro. Additionally, Tulp1 contributes to the stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages, implicating its involvement in cellular clearance mechanisms. Tulp1 forms homodimers and may interact with proteins such as ABCF1, PSIP1, ZEB1, HMGB2, DNM1, F-actin, TUB, and TYRO3, suggesting a diverse range of potential interactions that contribute to its multifaceted role in cellular processes.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-8*His
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Accession
O00294-2 (M1-E489)
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Gene ID/
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Molecular Construction
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N-term
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8*His
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Tulp1 (M1-E489)
Accession # O00294-2 -
C-term
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Protein Length
Full Length of Isoform-2
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Synonyms
TULP1; TUBL1; Tubby-related protein 1; Tubby-like protein 1; Tubby-Like Protein; Tubby-Like Protein 1; LCA15; TUB Like Protein 1; RP14
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AA Sequence
MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE
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Predicted Molecular Mass
55.8 kDa
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Molecular Weight
Approximately 56 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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