ROS inducer 4
ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic signaling in mitochondria.
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- CAS No.: 2959444-40-5
- Formule: C49H62BrO4P
- Masse moléculaire:825.89
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
ROS inducer 4 (compound TE3) shows anticancer activity against HeLa, A549, and HCT-15 cells with IC50 values of 4.83, 3.49, and 8.74 μM, respectively[1].
ROS inducer 4 (8 µM) disrupts mitochondrial function in HeLa cells by inducing ROS[1].
ROS inducer 4 (1-8 µM) induces cell apoptosis in HeLa cells in a dose-dependent manner[1].
ROS inducer 4 exhibits greatly enhanced anticancer activity compared to the parent molecule Ergosterol peroxide (HY-N3845)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ROS inducer 4 (1-2 mg/kg) has better anti-cervical cancer activity and safety than the Cisplatin (HY-17394), and can activate the immune response in mice[1].
ROS inducer 4 has moderate toxicity, ROS inducer 4 does not have significant toxic effects at an effective dose (1 mg/kg)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2959444-40-5
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Masse moléculaire 825.89
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Formule C49H62BrO4P
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SMILES
O=C(O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](/C=C/[C@H](C)C(C)C)C)CC[C@@]4([H])[C@@]3(OO5)C=C[C@@]25C1)CC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ROS inducer 4 Related Classifications
HY-159518 Related Classifications
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