RS-79948-197
RS-79948-197 is a non-imidazoline α2-adrenoceptor antagonist. RS-79948-197 shows Kd values of 0.42 nM, 0.18 nM, 0.19 nM, 0.60 nM, 0.46 nM, and 0.77 nM for rat α2A, rat α2B, rat α2C, human α2A, human α2B, and human α2C, respectively.
For research use only. We do not sell to patients.
- CAS No.: 186002-54-0
- Formula: C19H29ClN2O3S
- Molecular Weight:400.96
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
More
Biological Activity
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rat α2A receptor 0.42 nM (Kd) |
rat α2B recepter 0.18 nM (Kd) |
rat α2C recepter 0.19 nM (Kd) |
human α2A-adrenoceptor 0.6 nM (Kd) |
human α2B-adrenoceptor 0.46 nM (Kd) |
human α2C-adrenoceptor 0.77 nM (Kd) |
Chemical Information
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CAS No. 186002-54-0
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Appearance Solid
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Molecular Weight 400.96
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Formula C19H29ClN2O3S
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Color White to off-white
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SMILES
CCS(=O)(N1[C@@]2([H])C[C@@]3([H])C4=CC=C(OC)C=C4CCN3C[C@@]2([H])CCC1)=O.Cl
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Synonyms
RS-79948 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. S Uhlén, et al. [3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur J Pharmacol. 1998 Feb 5;343(1):93-101. [Content Brief]
[2]. Hume SP, et al. Evaluation in rat of RS-79948-197 as a potential PET ligand for central alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Dec 12;317(1):67-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RS-79948-197 Related Classifications
HY-101338 Related Classifications
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