S-14506 hydrochloride
Based on 1 Customer Validation
S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent.
For research use only. We do not sell to patients.
- Purity: 98.64%
- CAS No.: 286369-38-8
- Formula: C24H27ClFN3O2
- Molecular Weight:443.94
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT1A Receptor |
5-HT1 Receptor |
5-HT2A Receptor |
5-HT2C Receptor |
D2 Receptor |
S-14506 hydrochloride serves as 5-HT1A receptor agonist, appearing to be G(i) protein-dependent[4].
S-14506 hydrochloride (0.1 nM-100 μM; 10 min) shows high affinity for the G protein-uncoupled state of the 5-HT receptor in HeLa cells with pertussis toxin treatment[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
S-14506 hydrochloride (0.63 mg/kg; SC; single dose) is active in forced swimming test in rats. It induces imobility in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male swiss albino mice (25-30 g) and male Wistar rats (170-230 g)[2]
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Dosage:0.2 mg/kg, 0.8 mg/kg, 3.2 mg/kg, 3.8 mg/kg
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Administration:IP; single dose, 30 min before test
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Result:Inhibited stereotyped climbing and sniffing behaviours induced by dopamine agonists in mice and on spontaneous behaviours.
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Animal Model:Male Wistar rats (200-220 g)[3]
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Dosage:0.01 mg/kg, 0.63 mg/kg
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Administration:SC; and gave antagonist 30 min after agonist
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Result:Induced a dose-dependent imobility in rats.
Chemical Information
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CAS No. 286369-38-8
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Appearance Solid
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Molecular Weight 443.94
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Formula C24H27ClFN3O2
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Color White to off-white
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SMILES
O=C(C1=CC=C(C=C1)F)NCCN2CCN(CC2)C3=C4C=C(C=CC4=CC=C3)OC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL (563.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Protais P, et al. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77. [Content Brief]
[3]. Schreiber R, et al. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur J Pharmacol. 1994 Dec 27;271(2-3):537-41. [Content Brief]
[4]. Assié MB, et al. Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity. Eur J Pharmacol. 1999 Dec 10;386(1):97-103. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2526 mL | 11.2628 mL | 22.5256 mL | 56.3139 mL |
| 5 mM | 0.4505 mL | 2.2526 mL | 4.5051 mL | 11.2628 mL | |
| 10 mM | 0.2253 mL | 1.1263 mL | 2.2526 mL | 5.6314 mL | |
| 15 mM | 0.1502 mL | 0.7509 mL | 1.5017 mL | 3.7543 mL | |
| 20 mM | 0.1126 mL | 0.5631 mL | 1.1263 mL | 2.8157 mL | |
| 25 mM | 0.0901 mL | 0.4505 mL | 0.9010 mL | 2.2526 mL | |
| 30 mM | 0.0751 mL | 0.3754 mL | 0.7509 mL | 1.8771 mL | |
| 40 mM | 0.0563 mL | 0.2816 mL | 0.5631 mL | 1.4078 mL | |
| 50 mM | 0.0451 mL | 0.2253 mL | 0.4505 mL | 1.1263 mL | |
| 60 mM | 0.0375 mL | 0.1877 mL | 0.3754 mL | 0.9386 mL | |
| 80 mM | 0.0282 mL | 0.1408 mL | 0.2816 mL | 0.7039 mL | |
| 100 mM | 0.0225 mL | 0.1126 mL | 0.2253 mL | 0.5631 mL |
S-14506 hydrochloride Related Classifications
HY-110024 Related Classifications
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