S 1592
S 1592 is a compound with bronchodilatory and anti-allergic properties. S 1592 significantly suppresses cough caused by respiratory chemical or mechanical stimulation or superior laryngeal nerve electrical stimulation, without affecting gastrointestinal motility, and has low acute toxicity. S 1592 can be used for research on allergic diseases.
For research use only. We do not sell to patients.
- CAS No.: 25552-58-3
- Formula: C21H27ClN2O3
- Molecular Weight:390.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
S 1592 (i.p.) exhibits LD50s of 157 mg/kg and 251 mg/kg in rats and mice, respectively[1].
S 1592 (i.p.) at LD50 doses causes muscle weakness, irritability, and respiratory distress in mice and rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 25552-58-3
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Molecular Weight 390.90
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Formula C21H27ClN2O3
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SMILES
O=C(C1=CC=CC=C1O)NCC2(CCN(CC2)CCC3=CC=CC=C3)O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Acute Systemic Toxicity Study
Acute systemic toxicity studies evaluate adverse effects occurring after a single exposure, or repeated exposure within a short acute window, and the main in vivo readouts are mortality, moribund condition, clinical signs, body-weight change, and gross pathological findings; acute oral toxicity methods were developed to replace classical LD50 testing with reduced-animal designs such as fixed-dose procedure, acute toxic class method, and up-and-down procedure. The fixed-dose procedure classifies acute toxicity by administering predefined dose levels and observing evident toxicity rather than using death as the primary endpoint, whereas the acute toxic class method uses sequential groups of three animals per step and the up-and-down procedure doses animals sequentially to estimate an LD50 with fewer animals than conventional LD50 testing.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
S 1592 Related Classifications
HY-123220 Related Classifications
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