S24–14
S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC50 value of 0.40 µM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss.
For research use only. We do not sell to patients.
- CAS No.: 2348566-35-6
- Formula: C19H12N2O3S
- Molecular Weight:348.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | IC50 |
0.4 μM
Compound: S24-14
|
Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis
Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis
|
[PMID: 39167391] |
| RAW264.7 | CC50 |
65.46 μM
Compound: S24-14
|
Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by CCK-8 assay
Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by CCK-8 assay
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[PMID: 39167391] |
Chemical Information
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CAS No. 2348566-35-6
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Molecular Weight 348.38
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Formula C19H12N2O3S
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SMILES
O=C(C1=C(C=C2C(C=CC=C2)=C1)C(NC3=NC4=CC=CC=C4S3)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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