SARS-CoV-2-IN-57
SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 (IC50: 80 nM). SARS-CoV-2-IN-57 has high affinity for Sigma Receptor with Kis of 13.6 nM (S1R) and 14.4 nM (S2R) respectively.
For research use only. We do not sell to patients.
- CAS No.: 1265624-68-7
- Formula: C23H37N3O
- Molecular Weight:371.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Sigma Receptor Isoforms
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Biological Activity
Description
IC50 & Target
IC50: 80 nM (SARS-CoV-2)
Ki: 13.6 nM (S1R) 和 14.4 nM (S2R)[1]
Chemical Information
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CAS No. 1265624-68-7
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Molecular Weight 371.56
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Formula C23H37N3O
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SMILES
COC1=C(CCC[C@H]2NCCN3CCN(C4CCCCC4)CC3)C2=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)