SDH-IN-51
SDH-IN-51 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.16 μM against Rhizoctonia solani. SDH-IN-51 inhibits succinate dehydrogenase in the fungal mitochondrial respiratory chain, disrupting energy production. SDH-IN-51 disrupts fungal cell wall or membrane integrity, leading to mycelial morphological abnormalities. SDH-IN-51 exhibits protective and curative antifungal efficacy against Rhizoctonia solani on rice leaves in detached leaf assays. SDH-IN-51 can be used for research on rice sheath blight.
For research use only. We do not sell to patients.
- Formula: C26H19ClN2O
- Molecular Weight:410.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
[1]|
SDH 0.16 μM (IC50) |
In Vitro
SDH-IN-51 (compound 6g) (20 μg/mL) exhibits excellent antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum, with inhibition rates of 99.2% and 93.5% at 20 μg/mL, respectively[1].
SDH-IN-51 exhibits excellent antifungal activity against Rhizoctonia solani with an EC50 of 0.008 μg/mL and shows significant activity against Sclerotinia sclerotiorum with an EC50 of 0.182 μg/mL[1].
SDH-IN-51 effectively inhibits Rhizoctonia solani SDH with an IC50 of 0.16 μM[1].
SDH-IN-51 (1 μg/mL) causes severe morphological disruption of Rhizoctonia solani hyphae, including shrinkage and atrophy[1].
SDH-IN-51 (100 μg/mL) exhibits potent antifungal activity against R. solani on rice leaves, with protective and curative efficacies of 99.08% and 93.01%, respectively, at 100 μg/mL[1].
SDH-IN-51 binds to the active site of Rhizoctonia solani SDH, forming key hydrogen bonds with TYR91 and TRP173, and hydrophobic interactions with VAL87 and ILE50[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 410.89
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Formula C26H19ClN2O
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SMILES
O=C(NC1=CC=CC=C1/C=C/C2=CC=C(C3=CC=CC=C3)C=C2)C4=C(Cl)N=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)