PTK2B - protein tyrosine kinase 2 beta Gene

Also Known as PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2185

About PTK2B

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:27,310,506-27,459,391 (from NCBI)

This gene has 17 transcripts (splice variants), 269 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 29.2), bone marrow (RPKM 29.0) and 24 other tissues.

Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of Protein Tyrosine Kinases but lacks significant sequence similarity to kinases from Other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTK2B Products (4)

mRNA	Protein	Name
NM_004103.4	NP_004094.3	protein-tyrosine kinase 2-beta isoform a
NM_173174.3	NP_775266.1	protein-tyrosine kinase 2-beta isoform a
NM_173175.2	NP_775267.1	protein-tyrosine kinase 2-beta isoform b
NM_173176.3	NP_775268.1	protein-tyrosine kinase 2-beta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7544443	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8849729	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of Janus kinase activity	IMP IMP: Inferred from mutant phenotype	8670418	GOA
involved in cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8849729	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in endothelin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19086031	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15050747	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19880522	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15050747	GOA
involved in negative regulation of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	15050747	GOA
involved in negative regulation of potassium ion transport	IDA IDA: Inferred from direct assay	7544443	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	9545257	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7544443	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	7544443	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	8670418	GOA
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	18765415	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18765415	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18765415	GOA
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	18765415	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	21245381	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	7544443	GOA
involved in regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	19086031	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	19086031	GOA
involved in regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19880522	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	8670418	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	18765415	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	18765415	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19880522	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18765415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTK2B Protein Structure

FERM_M

Pkinase_Tyr

Focal_AT

0
200
400
600
800
1009 a.a.

Protein Preferred Names	Protein Names
protein-tyrosine kinase 2-beta	CAK-beta

PTK2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTK2B	Q14289	RHOU	Homo sapiens	Q7L0Q8	Pull Down	18086875
Intra	PTK2B	Q14289	RHOU	Homo sapiens	Q7L0Q8	Anti Tag CoIP	18086875
Intra	PTK2B	Q14289	NPHP4	Homo sapiens	O75161	Anti Bait CoIP	15661758
Intra	PTK2B	Q14289	FYN	Homo sapiens	P06241	Pull Down	10867021
Intra	PTK2B	Q14289	FYN	Homo sapiens	P06241	Pull Down	32707033
Intra	PTK2B	Q14289	FYN	Homo sapiens	P06241	Y2H Fragment Pooling	31413325
Intra	PTK2B	Q14289	SRC	Homo sapiens	P12931	Pull Down	10521452
Intra	PTK2B	Q14289	SRC	Homo sapiens	P12931	CoIP	11149930

Cross: Cross-species interaction Intra: Intraspecies interaction

PTK2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80290	PYK2 Antibody (YA115)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P80877	PYK2 Antibody (YA682)	WB, IHC-P	Human
HY-P80877A	PYK2 Antibody (YA682)(PBS only)	WB, IHC-P	Human
HY-P84568	PYK2 Antibody (YA4265)	WB, IHC-P, ELISA	Human
HY-P84568A	PYK2 Antibody (YA4265)(PBS only)	WB, IHC-P, ELISA	Human
HY-P85341	PYK2 Antibody (YA5033)	WB; IHC-P; ICC/IF; IF-Tissue; FC; IHC-F	Human, Mouse, Rat
HY-P85462	PYK2 Antibody (YA5154)	WB	Human, Mouse, Dog, Pig, Rabbit
HY-P86140	PYK2 Antibody (YA5832)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Cone-Rod Dystrophy 5	CORD5 Dystrophy, Cone-Rod, Type 5
Glioma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Retinal Degeneration	Degeneration Of Retina
Mixed Cell Adenoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-RS26981	Ptk2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11402	PTK2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20473	Ptk2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTK2B	RGD	RGD:628758
Bos taurus	PTK2B	VGNC	VGNC:33519
Macaca mulatta	PTK2B	VGNC	VGNC:76593
Canis familiaris	PTK2B	VGNC	VGNC:45159
Felis catus	PTK2B	VGNC	VGNC:69153
Mus musculus	PTK2B	MGD	MGI:104908
Others	PTK2B	NCBI