SNX17 - sorting nexin 17 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9784

About SNX17

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,370,616-27,377,535 (from NCBI)

This gene has 10 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.0), lymph node (RPKM 26.3) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

SNX17 Products (4)

mRNA Protein Name
NM_001267059.2 NP_001253988.1 sorting nexin-17 isoform 2
NM_001267060.2 NP_001253989.1 sorting nexin-17 isoform 3
NM_001267061.2 NP_001253990.1 sorting nexin-17 isoform 4
NM_014748.4 NP_055563.1 sorting nexin-17 isoform 1

SNX17 Protein Structure

PX

PX: PX domain (11 - 103)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 470 a.a.
Protein Preferred Names Protein Names

sorting nexin-17

SNX17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SNX17 Q15036 HOXC8 Homo sapiens P31273
Y2H Array
32296183
Intra
SNX17 Q15036 HOXC8 Homo sapiens P31273
Y2H Prey Pooling
32296183
Intra
SNX17 Q15036 RNF128 Homo sapiens Q8TEB7
Y2H Array
32296183
Intra
SNX17 Q15036 RNF128 Homo sapiens Q8TEB7
Y2H Prey Pooling
32296183
Intra
SNX17 Q15036 RNF128 Homo sapiens Q8TEB7
Validated Y2H
32296183
Intra
SNX17 Q15036 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
SNX17 Q15036 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
Intra
SNX17 Q15036 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra
SNX17 Q15036 RABAC1 Homo sapiens Q9UI14
Y2H Array
32296183
Intra
SNX17 Q15036 PLCG1 Homo sapiens P19174
Peptide Array
17474147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypercholesterolemia, Familial, 4

  • Hypercholesterolemia, Autosomal Recessive

  • Arh

  • FHCL4

  • Autosomal Recessive Hypercholesterolemia

  • Arh1

  • Arh2

  • Autosomal Recessive Hypercholesterolemia 1

  • Autosomal Recessive Hypercholesterolemia 2

  • Fhcb1

  • Fhcb2

  • Hypercholesterolemia, Autosomal Recessive, 1, Formerly

  • Arh1, Formerly

  • Fhcb1, Formerly

  • Hypercholesterolemia, Autosomal Recessive, 2, Formerly

  • Arh2, Formerly

  • Fhcb2, Formerly

  • Familial Autosomal Recessive Hypercholesterolemia

  • Hypercholesterolemia, Familial, Autosomal Recessive

  • Hypercholesterolemia, Familial, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13530 SNX17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SNX17 RGD RGD:1306424
Mus musculus SNX17 MGD MGI:2387801
Macaca mulatta SNX17 VGNC VGNC:77709
Bos taurus SNX17 VGNC VGNC:35097
Canis familiaris SNX17 VGNC VGNC:46626
Felis catus SNX17 VGNC VGNC:65547
Others SNX17 NCBI