MRV03-068
Based on 1 Customer Validation
MRV03-068 (Compound 2) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-068 can be used in colorectal cancer research.
For research use only. We do not sell to patients.
- Purity : 98.46%
- CAS No.: 2797066-17-0
- Formula: C20H25BN2O4
- Molecular Weight:368.23
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
ClbP[1].
Chemical Information
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CAS No. 2797066-17-0
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Appearance Solid
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Molecular Weight 368.23
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Formula C20H25BN2O4
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Color White to off-white
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SMILES
O=C(C1=CC(C=CC=C2)=C2C=C1)N[C@H](CC(N)=O)B3OC(C)(C)C(C)(C)O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (271.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7157 mL | 13.5785 mL | 27.1569 mL | 67.8923 mL |
| 5 mM | 0.5431 mL | 2.7157 mL | 5.4314 mL | 13.5785 mL | |
| 10 mM | 0.2716 mL | 1.3578 mL | 2.7157 mL | 6.7892 mL | |
| 15 mM | 0.1810 mL | 0.9052 mL | 1.8105 mL | 4.5262 mL | |
| 20 mM | 0.1358 mL | 0.6789 mL | 1.3578 mL | 3.3946 mL | |
| 25 mM | 0.1086 mL | 0.5431 mL | 1.0863 mL | 2.7157 mL | |
| 30 mM | 0.0905 mL | 0.4526 mL | 0.9052 mL | 2.2631 mL | |
| 40 mM | 0.0679 mL | 0.3395 mL | 0.6789 mL | 1.6973 mL | |
| 50 mM | 0.0543 mL | 0.2716 mL | 0.5431 mL | 1.3578 mL | |
| 60 mM | 0.0453 mL | 0.2263 mL | 0.4526 mL | 1.1315 mL | |
| 80 mM | 0.0339 mL | 0.1697 mL | 0.3395 mL | 0.8487 mL | |
| 100 mM | 0.0272 mL | 0.1358 mL | 0.2716 mL | 0.6789 mL |
MRV03-068 Related Classifications
HY-151628 Related Classifications
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