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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
324 Results for "
clone
" in MedChemExpress (MCE) Product Catalog:
Products (324)
324 Results for "clone" in MCE Product Catalog:
Cat. No.: HY-P990303
Research Areas:
Cat. No.: HY-184005
IHMT-BMX-068 is a BMX PROTAC degrader with a DC50 of 0.007 μM. IHMT-BMX-068 promotes ubiquitination and degradation of BMX. IHMT-BMX-068 increases the levels of cleaved PARP and cleaved Caspase-3, and induces Apoptosis. IHMT-BMX-068 exerts anti-cancer effects against prostate cancer. IHMT-BMX-068 can be used for the research of prostate cancer .
Synonyms: Rec 15/2739; Recordati 15/2739; SB 216469
Target:
Research Areas:
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .
Synonyms: 5-CT
Target:
Research Areas:
5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist . 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice .
Cat. No.: HY-19210
CAS No.: 157659-79-5
Target:
Research Areas:
SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (Ki=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty .
Cat. No.: HY-W194842
CAS No.: 525-41-7
Target:
Target:
Research Areas:
A-61603 is a selective α1A/α1a-adrenergic receptor agonist with Ki of 8.89 nM for rat submaxillary gland α1A, Ki of 30.5 nM for cloned bovine α1a. A-61603 potentiates Ca 2+ transients with EC50 of 6.9 nM. A-61603 stimulates phosphoinositide hydrolysis, induces contractile responses in vas deferens, prostate strips, and spleen strips, and exhibits low activity in aortic rings. A-61603 can be used for research on adrenergic function .
Cat. No.: HY-156094
CAS No.: 2883046-06-6
Target:
Research Areas:
JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion .
Cat. No.: HY-17038S1
CAS No.: 1079389-44-8
Synonyms: S-20098-d4
Cat. No.: HY-17038S2
CAS No.: 1079389-38-0
Synonyms: S-20098-d3
Cat. No.: HY-172901
Target:
Research Areas:
AMPK activator 17 (Compound 10g) is an orally active AMPK activator. AMPK activator 17 has significant anti-adipogenic (IC50: 3.4 μM) and dyslipidemia-modifying activities. AMPK activator 17 inhibits the early stages of adipocyte differentiation (mitotic clonal expansion) by activating the AMPK pathway. AMPK activator 17 can enhance mitochondrial function and fatty acid oxidation in mature adipocytes. AMPK activator 17 improves dyslipidemia by promoting reverse cholesterol transport. AMPK activator 17 can be used in the study of obesity and related metabolic diseases (such as type 2 diabetes and cardiovascular disease) .
Cat. No.: HY-175263
CAS No.: 38239-51-9
Research Areas:
Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures .
Cat. No.: HY-P703353
Synonyms: SLC22A23; Chromosome 6 Open Reading Frame 85; Prev. C6orf85; CDNA: FLJ21380 Fis, clone COL03329; FLJ22174; Ion Transporter Protein; Solute Carrier Family 22, Member 23; SLC22A23 Protein; Solute Carrier Family 22 Member 23; CDNA: FLJ22174 Fis, clone HRC007
Species:
Human
Source:
HEK293
Cat. No.: HY-P703936
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SLC22A23; Chromosome 6 Open Reading Frame 85; Prev. C6orf85; CDNA: FLJ21380 Fis, clone COL03329; FLJ22174; Ion Transporter Protein; Solute Carrier Family 22, Member 23; SLC22A23 Protein; Solute Carrier Family 22 Member 23; CDNA: FLJ22174 Fis, clone HRC007
Species:
Human
Source:
HEK293
Cat. No.: HY-P704203
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Allergen Ara h 1; Ara h 1; clone P17; Allergen Ara h I; allergen Ara h 1
Species:
Others
Source:
E. coli
Cat. No.: HY-P70291
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IDE; Insulin Protease; Insulin Degrading Enzyme; Abeta-Degrading Protease; Insulin-Degrading Enzyme; Insulinase; Insulysin; CDNA FLJ35968 Fis, clone TESTI2013053, Highly Similar To INSULIN-DEGRADING ENZYME
Species:
Human
Source:
HEK293
Category:
Alkaloids Ricinus communis L. Other Diseases Pyridine Alkaloids Euphorbiaceae Plants Disease Research Fields
Target:
Cat. No.: HY-121944R
CAS No.: 524-40-3
Target:
Cat. No.: HY-121944S
CAS No.: 1313734-77-8
Ricinine-d3 is the d3-labeled Ricinine (HY-121944). Ricinine is a central nervous system stimulant found in Ricinus communis. Ricinine binds near the benzodiazepine site of the GABAA receptor, reducing benzodiazepine binding affinity through an allosteric effect, and shows no interaction with AMPA, 5-HT1A, muscarinic receptors, or α1 adrenergic receptors. Ricinine improves memory consolidation in mice at low doses, while at high doses it induces seizures, an effect that is selectively inhibited by diazepam. Ricinine shortens the lifespan of Anopheles mosquitoes through sugar feeding and promotes the development of Plasmodium falciparum in mosquitoes . Ricinine is used in research related to epilepsy, amnesia, and malaria .
Synonyms: CPA; UK-80882
Target:
Research Areas:
N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
