2248 Results for "

calcium complexant

" in MedChemExpress (MCE) Product Catalog:

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L-Lysine (Standard)

Cat. No.: HY-N0469R

CAS No.: 56-87-1

Category:

Microorganisms Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite

Target:

Reference Standards Endogenous Metabolite Virus Protease HSV

L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation . IC₅₀ & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium .
L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity . In Vivo:L-lysine (10?mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model . L-lysine (5 or 10?mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model .

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β-Amyloid (1-42), human, Ala(13C3,15N) TFA

Cat. No.: HY-P1363S1

Target:

Isotope-Labeled Compounds Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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6:2 Fluorotelomer alcohol

Cat. No.: HY-W002199

CAS No.: 647-42-7

Synonyms: 6:2 FTOH; 1H,1H,2H,2H-Perfluoro-1-octanol; 2-(Perfluorohexyl)ethanol

Target:

Bacterial Apoptosis ERK TNF Receptor

Research Areas:

Infection Neurological Disease

6:2 Fluorotelomer alcohol (6:2 FTOH) is an orally active, blood-brain barrier-permeable modulator of cyclin D1 and ETS1. 6:2 Fluorotelomer alcohol downregulates cyclin D1 expression, upregulates ETS1 via the TNF-α/ERK 1/2 pathway, impairs mitochondrial membrane potential and respiratory function, increases reactive oxygen species levels, disrupts calcium homeostasis and activates endoplasmic reticulum stress markers, and induces cell proliferation inhibition and endothelial-mesenchymal transition. Furthermore, 6:2 Fluorotelomer alcohol induces morphological abnormalities in zebrafish embryos and liver developmental damage, while disrupting the brain immune microenvironment in mice, causing systemic toxicity and delayed pup maturation in CD-1 mice. 6:2 Fluorotelomer alcohol also induces cortical neuron apoptosis, glial cell activation, synaptic abnormalities, colonic barrier damage, intestinal dysbiosis and autism spectrum disorder-like symptoms in mice. 6:2 Fluorotelomer alcohol shows no mutagenic, clastogenic, primary skin/eye irritation or skin sensitizing effects, exhibits no selective reproductive toxicity in CD-1 mice, and is classified as GHS Category 4 for acute oral toxicity. 6:2 Fluorotelomer alcohol can be used in studies of neurodevelopmental disorders and autism spectrum disorders .

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Pectolinarigenin (Standard)

Cat. No.: HY-N0493R

CAS No.: 520-12-7

Category:

Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Extract

Target:

Reference Standards COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy

Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma.

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N Cadherin Antibody (YA4680)

Cat. No.: HY-P84988

Synonyms: CADH2_HUMAN antibody; Cadherin 2 antibody; Cadherin 2 N cadherin neuronal antibody; Cadherin 2 type 1 antibody; Cadherin 2 type 1 N cadherin neuronal antibody; Cadherin 2; type 1; N-cadherin; neuronal; antibody; Cadherin-2 antibody; Cadherin2 antibody; calcium dependent adhesion protein neuronal antibody; CD325 antibody; CD325 antigen antibody; CDH2 antibody; CDHN antibody; CDw325 antibody; CDw325 antigen antibody; N cadherin 1 antibody; N-cadherin antibody; NCAD antibody; Neural cadherin antibody; OTTHUMP00000066304 antibody; OTTHUMP00000067378 antibody; CD325 nanobody;

Host:

Mouse

Application:

FC, ELISA

Reactivity:

Human

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NCS1 Antibody (YA6673)

Cat. No.: HY-P86980

Synonyms: 9430075O15Rik antibody; A730032G13Rik antibody; AI836659 antibody; DKFZp761L1223 antibody; FLUP antibody; FREQ antibody; Frequenin antibody; Frequenin homolog (Drosophila) antibody; Frequenin homolog antibody; Frequenin like protein antibody; 9430075O15Rik antibody; A730032G13Rik antibody; AI836659 antibody; DKFZp761L1223 antibody; FLUP antibody; FREQ antibody; Frequenin antibody; Frequenin homolog (Drosophila) antibody; Frequenin homolog antibody; Frequenin like protein antibody; Frequenin, Drosophila, homolog of antibody; Frequenin-like protein antibody; Frequenin-like ubiquitous protein antibody; Mfreq antibody; NCS 1 antibody; NCS-1 antibody; ncs1 antibody; NCS1_HUMAN antibody; Neuronal calcium sensor 1 antibody; Neuronal Calicum Sensor 1 antibody;

Host:

Rabbit

Application:

Reactivity:

Human, Mouse, Rat

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EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, Fc-Avi)

Cat. No.: HY-P78883

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: EPCAM; HEA125; Prev. TACSTD1; CO-17A; Prev. MIC18; EGP314; Prev. M4S1; EGP34; Tumor-Associated calcium Signal Transducer 1; CD326; TROP1; MOC31; KSA; 17-1A; GA733-2; Ly74; Ber-Ep4; MH99; Ep-CAM; Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein); MOC-31; Antigen Identified By Monoclonal Antibody AUA1; BerEp4; Human Epithelial Glycoprotein-2; EGP40; Epithelial Cell Surface Antigen; EGP-2; Epithelial Glycoprotein; KS1/4; KS 1/4 Antigen; MK-1; CD326 Antigen; ESA; HEGP314; Major Gastrointestinal Tumor-Associated Protein GA733-2; HNPCC8; Trophoblast Cell Surface Antigen 1; LYNCH8; Adenocarcinoma-Associated Antigen; DIAR5; Cell Surface Glycoprotein Trop-1; M1S2; Epithelial Glycoprotein 314; EGP; TACST-1; Epithelial Cell Adhesion Molecule; 323/A3

Species:

Human

Source:

HEK293

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EpCAM/TROP1 Protein, Human (HEK293, mFc)

Cat. No.: HY-P704581

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Species:

Human

Source:

HEK293

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