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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
ASGPR
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "ASGPR" in MCE Product Catalog:
Cat. No.: HY-145649A
CAS No.: 2380166-34-5
Synonyms: AD-85481 sodium; ALN-AGT sodium
Research Areas:
Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension .
Cat. No.: HY-146152
CAS No.: 2052968-88-2
ASGPR modulator-1 (Compound 5TJX) is a macrocycle compound that can be uesd for protein-protein interaction study .
Cat. No.: HY-112752
CAS No.: 219850-70-1
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles .
Cat. No.: HY-RS01085
Target:
Research Areas:
ASGR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ASGR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-142885
CAS No.: 2378837-56-8
M-MoDE-A (2) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).
Cat. No.: HY-P704414
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ASGR1; ASGR1 Protein; Asialoglycoprotein Receptor 1; ASGP-R 1; CLEC4H1; ASGPR 1; C-Type Lectin Domain Family 4 Member H1; ASGPR1; Hepatic Lectin H1; ASGPR; HL-1
Species:
Mouse
Source:
HEK293
Cat. No.: HY-185590
CAS No.: 3084453-02-8
Research Areas:
tri-GalNAc-phosphoric acid is a specific ligand of ASGPR with cell-specific internalization capability. tri-GalNAc-phosphoric acid can mediate the delivery of conjugated sclerostin aptamers to lysosomes of cells expressing ASGPR. tri-GalNAc-phosphoric acid is applicable to anticancer research .
Cat. No.: HY-180909
Research Areas:
TMU454 is an ASGPR-targeting GalNAc-PROTAC BRD4 degrader conjugate. TMU454 undergoes ASGPR-mediated endocytosis and CTSB cleavage to release MZ1, which selectively degrades BRD4 in ASGPR-positive hepatocellular carcinoma cells via the VHL/UPS/proteasome pathway. TMU454 inhibits cancer cell proliferation and colony formation, and suppresses tumor growth in vivo. TMU454 can be used for research related to hepatocellular carcinoma .
Cat. No.: HY-171342
CAS No.: 2893765-20-1
Research Areas:
Mal-C2-amide-C10-tri-GalNAc is an asialoglycoprotein receptor (ASGPR) binding ligand fragment and a component of lysosome-targeted bifunctional molecules. Mal-C2-amide-C10-tri-GalNAc is used in the research of autoimmune diseases .
Cat. No.: HY-P704413
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ASGR1; ASGR1 Protein; Asialoglycoprotein Receptor 1; ASGP-R 1; CLEC4H1; ASGPR 1; C-Type Lectin Domain Family 4 Member H1; ASGPR1; Hepatic Lectin H1; ASGPR; HL-1
Species:
Human
Source:
HEK293
Cat. No.: HY-P705990
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ASGR1; ASGR1 Protein; Asialoglycoprotein Receptor 1; ASGP-R 1; CLEC4H1; ASGPR 1; C-Type Lectin Domain Family 4 Member H1; ASGPR1; Hepatic Lectin H1; ASGPR; HL-1
Species:
Rat
Source:
HEK293
Cat. No.: HY-P703720
Purity: ≥ 95%, as determined by reducing SDS-PAGE.;≥ 90%, as determined by HPLC.
Synonyms: CLEC4H1; ASGR1; Hepatic lectin H1; HL-1; C-type lectin domain family 4 member H1; ASGP-R 1; ASGPR 1; Asialoglycoprotein receptor 1
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-19272
CAS No.: 185843-61-2
Research Areas:
OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
