24 Results for "

FEN1

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "FEN1" in MCE Product Catalog:

Cat. No.: HY-P80669
Synonyms: FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1

Host:  

Mouse

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P80669A
Synonyms: FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1

Host:  

Mouse

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-183454
CAS No.: 882278-66-2
Target:  

FLAP

Research Areas:  

Cancer

JFD00950 is a human FEN1 inhibitor with an IC50 of 5.5 μM. JFD00950 binds directly to FEN1, alters the secondary structure of this protein, and competitively inhibits its flap cleavage activity by interfering with substrate binding. JFD00950 selectively reduces the viability of cancer cells. JFD00950 can be used in the research of colon cancer and breast cancer [1].
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Cat. No.: HY-183488
CAS No.: 1207092-73-6
Synonyms: RRRRRRRRRCCLGIPEQEY
Target:  

Apoptosis PARP

Research Areas:  

Cancer

R9-caPep (RRRRRRRRRCCLGIPEQEY) is a cell-penetrating peptide derived from proliferating cell nuclear antigen (PCNA). R9-caPep selectively blocks the interactions between PCNA and FEN1, as well as between PCNA and LIGI, while preserving the binding of POLD3 to PCNA. R9-caPep interferes with DNA synthesis and homologous recombination-mediated double-strand DNA break repair, inducing S-phase arrest, DNA damage accumulation, and apoptosis. R9-caPep inhibits the growth of tumor volume and weight of neuroblastoma in nude mice . R9-caPep can be used in research related to neuroblastoma and triple-negative breast cancer [1] .
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