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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
LOXL2
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "LOXL2" in MCE Product Catalog:
Cat. No.: HY-180585
Research Areas:
LOXL2/sGC modulator-2 (Compound 9k) is a selective and orally active lysyl oxidase-like 2 (LOXL2) and soluble guanylate cyclase (sGC) dual-target regulator. LOXL2/sGC modulator-2 shows inhibitory activity for LOXL2 with an IC50 of 0.1 μM and can activate sGC. LOXL2/sGC modulator-2 can ameliorate vascular remodeling and reduce pulmonary artery pressure. LOXL2/sGC modulator-2 can downregulate PKG1, PCNA, α-SMA, collagen I and fibronectin levels. LOXL2/sGC modulator-2 can be used for the research of pulmonary arterial hypertension .
Cat. No.: HY-180581
Target:
Research Areas:
LOXL2/sGC modulator-1 (Compound 11k) is a LOXL2 inhibitor (IC₅₀ = 0.13 μM) and an sGC activator. LOXL2/sGC modulator-1 shows good selectivity for LOX (IC₅₀ > 45.9 μM) and LOXL3 (IC₅₀ = 1.30 μM). LOXL2/sGC modulator-1 significantly increases intracellular cGMP levels in the presence of the gGC inhibitor ODQ (HY-101255). LOXL2/sGC modulator-1 significantly inhibits hypoxia-induced collagen deposition and cross-linking, while promoting vasodilation. LOXL2/sGC modulator-1 can be used for the study of pulmonary arterial hypertension .
Cat. No.: HY-107422A
CAS No.: 2098884-53-6
Synonyms: PAT-1251 hydrochloride; GB2064 hydrochloride
Target:
Research Areas:
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases.
Cat. No.: HY-183644
Target:
Research Areas:
LNO 9 is an orally active LOXL2 inhibitor and NO donor, with an IC50 of 0.17 μM against human LOXL2. LNO 9 competitively binds to the LTQ cofactor of LOXL2 to form an irreversible complex, thereby inhibiting collagen oxidation and abnormal cross-linking. LNO 9 releases nitric oxide (NO) to increase cGMP levels in pulmonary artery smooth muscle cells. LNO 9 inhibits hypoxia-induced collagen modification and possesses vasodilatory activity. LNO 9 ameliorates right ventricular hypertrophy and pulmonary artery medial thickness in rat models induced by hypoxia and Monocrotaline (HY-N0750), and can be used for research on pulmonary hypertension .
Cat. No.: HY-W036566
CAS No.: 54-97-7
Target:
Research Areas:
2-Phenylcyclopropanamine (Compound 3) is an irreversible inhibitor of MAO-A/B and LSD1. 2-Phenylcyclopropanamine shows no activity against LOXL2 .
Cat. No.: HY-P74771
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LOXL2; Lysyl Oxidase-Related Protein 2; Lysyl Oxidase Like 2; Lysyl Oxidase-Like 2 Delta E13; Lysyl Oxidase-Like Protein 2; Lysyl Oxidase-Like 2 Protein; Lysyl Oxidase Homolog 2; Lysyl Oxidase Related 2; WS9-14; Lysyl Oxidase Homolog; LOR; Lysyl Oxidase-L
Species:
Human
Source:
CHO
Cat. No.: HY-P74770Y
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LOXL2; Lysyl Oxidase-Related Protein 2; Lysyl Oxidase Like 2; Lysyl Oxidase-Like 2 Delta E13; Lysyl Oxidase-Like Protein 2; Lysyl Oxidase-Like 2 Protein; Lysyl Oxidase Homolog 2; Lysyl Oxidase Related 2; WS9-14; Lysyl Oxidase Homolog; LOR; Lysyl Oxidase-L
Species:
Human
Source:
HEK293
Cat. No.: HY-107422R
CAS No.: 2007885-39-2
Synonyms: PAT-1251 (Standard); GB2064 (Standard)
Target:
Research Areas:
Lenumlostat (Standard) is the analytical standard of Lenumlostat (HY-107422). This product is intended for research and analytical applications. PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases .
Cat. No.: HY-P74769
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LOXL2; Lysyl Oxidase-Related Protein 2; Lysyl Oxidase Like 2; Lysyl Oxidase-Like 2 Delta E13; Lysyl Oxidase-Like Protein 2; Lysyl Oxidase-Like 2 Protein; Lysyl Oxidase Homolog 2; Lysyl Oxidase Related 2; WS9-14; Lysyl Oxidase Homolog; LOR; Lysyl Oxidase-L
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74769Y
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LOXL2; Lysyl Oxidase-Related Protein 2; Lysyl Oxidase Like 2; Lysyl Oxidase-Like 2 Delta E13; Lysyl Oxidase-Like Protein 2; Lysyl Oxidase-Like 2 Protein; Lysyl Oxidase Homolog 2; Lysyl Oxidase Related 2; WS9-14; Lysyl Oxidase Homolog; LOR; Lysyl Oxidase-L
Species:
Mouse
Source:
HEK293
Cat. No.: HY-101771AR
CAS No.: 916210-98-5
Target:
Research Areas:
(2-Chloropyridin-4-yl)methanamine hydrochloride (Standard) is the analytical standard of (2-Chloropyridin-4-yl)methanamine hydrochloride (HY-101771A). This product is intended for research and analytical applications. (2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.
Cat. No.: HY-RS21632
Target:
Research Areas:
Loxl3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Loxl3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
