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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
SMN2
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "SMN2" in MCE Product Catalog:
Cat. No.: HY-109101AS2
Cat. No.: HY-133895
CAS No.: 1449592-94-2
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Research Areas:
SMN-C5 is an inducer of SMN2 exon 7 inclusion. SMN-C5 binds to the SMN2 exon 7 5′-splice site/U1 snRNA helix (Kd = 28 μM) and positively allosterically modulates SMN2 splicing correction. SMN-C5 binds to SMN2 exon 7 ESE2 and partially displaces hnRNP G, enhances the affinity of U1 snRNP for the weak splice site, binds to a bulged adenine in the major groove and forms hydrogen bonds, while not affecting the interaction of Tra2-β1 with ESE2 RNA. SMN-C5 can be used for research on spinal muscular atrophy [2].
Cat. No.: HY-189605
CAS No.: 2407724-51-8
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Research Areas:
SMN modulator-1 is an SMN2 mRNA splicing modulator. SMN modulator-1 increases the expression of full-length SMN (FL-SMN) mRNA by promoting the inclusion of exon 7 in the SMN2 gene. SMN modulator-1 can be used in research related to spinal muscular atrophy (SMA) .
0 Images
RNA, [2'-O-(2-methylamino)-2-oxoethyl](m5C-sp-A-m5C-sp-m5U-m5U-sp-m5U-sp-m5C-sp-A-sp-m5U-sp-A-sp-A-sp-m5U-sp-G-sp-m5C-sp-m5U-sp-G-sp-G-sp-m5C), sodium salt
Cat. No.: HY-177661A
Synonyms: BIIB115 sodium; ION306 sodium
Cat. No.: HY-101792R
CAS No.: 1449598-06-4
Synonyms: RO6885247 (Standard)
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Research Areas:
RG7800 (Standard) (RO6885247 (Standard)) is the analytical standard of RG7800 (HY-101792). This product is intended for research and analytical applications. RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.
Cat. No.: HY-RS05838
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Research Areas:
Grm7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-111520R
CAS No.: 1562333-92-9
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NVS-SM2 (Standard) is the analytical standard of NVS-SM2 (HY-111520). This product is intended for research and analytical applications. NVS-SM2 is a potent, orally active and brain-penetrant SMN2 splicing enhancer with an EC50 of 2 nM for SMN. NVS-SM2 enhances U1-pre-mRNA association. NVS-SM2 promotes exon 7 inclusion and restores normal survival motor neuron (SMN) protein expression. NVS-SM2 can be used for spinal muscular atrophy (SMA) research [2].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
