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Cat. No.: HY-189605

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SMN modulator-1

SMN modulator-1 is an SMN2 mRNA splicing modulator. SMN modulator-1 increases the expression of full-length SMN (FL-SMN) mRNA by promoting the inclusion of exon 7 in the SMN2 gene. SMN modulator-1 can be used in research related to spinal muscular atrophy (SMA).

For research use only. We do not sell to patients.

CAS No.: 2407724-51-8
Formula: C₂₂H₂₃N₅O
Molecular Weight:373.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMN modulator-1 Chemical Structure

CAS No.: 2407724-51-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

SMN modulator-1 (compound 80) upregulates FL-SMN mRNA expression levels in SMA patient-derived fibroblasts (GM03813), with relative expression levels of 100%-120% compared to the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2407724-51-8
Molecular Weight 373.45
Formula C₂₂H₂₃N₅O
SMILES

O=C1C2=C(N=CN1C3CCN(CC3)C)C=CC(C4=CC5=NC(C)=CN5C=C4)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fuji K, et al. PROPHYLACTIC OR THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY. WO 2020/004594 A1.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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