Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
Smac
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "Smac" in MCE Product Catalog:
Cat. No.: HY-RS25999
Target:
Research Areas:
Diablo Rat Pre-designed siRNA Set A contains three designed siRNAs for Diablo gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS03762
Target:
Research Areas:
DIABLO Human Pre-designed siRNA Set A contains three designed siRNAs for DIABLO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19505
Target:
Research Areas:
Diablo Mouse Pre-designed siRNA Set A contains three designed siRNAs for Diablo gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-138059A
Purity: 98.57%
SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2) .
Cat. No.: HY-N0732R
CAS No.: 37905-08-1
Cat. No.: HY-P73416
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DIABLO; Second Mitochondria-Derived Activator Of Caspase; Diablo IAP-Binding Mitochondrial Protein; DIABLO-S; Smac; FLJ25049; Direct IAP-Binding Protein With Low PI; FLJ10537; Diablo Homolog, Mitochondrial; Diablo, IAP-Binding Mitochondrial Protein; DFNA6
Species:
Human
Source:
E. coli
Cat. No.: HY-16591R
CAS No.: 1260251-31-7
Synonyms: TL32711 (Standard)
Birinapant (Standard) is the analytical standard of Birinapant (HY-16591). This product is intended for research and analytical applications. Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.
Cat. No.: HY-181533
Target:
Research Areas:
IAP ligand 9 is an ASX-series, non-peptidic SMAC mimetic and IAP binder with high cell permeability. IAP ligand 9 selectively targets cIAP1-BIR3, XIAP-BIR3, exhibits extremely weak binding affinity for XIAP-BIR2, with a KD of 100 nM for cIAP1-BIR3 and 10 nM for XIAP-BIR2. IAP ligand 9 can be used to synthesize IAP-recruiting protein degraders (IPD), and can calibrate the cell permeability and cellular-level target binding assays of the IPD molecule SNIPER (TEAD)-1 (HY-181607). IAP ligand 9 and its series of degraders can be used in the research of solid tumors such as malignant pleural mesothelioma associated with abnormal activation of the Hippo pathway .
Cat. No.: HY-181532
Target:
Research Areas:
IAP ligand 8 is an ASX-series, non-peptidic SMAC mimetic and IAP binder with high cell permeability. IAP ligand 8 selectively targets cIAP1-BIR3, XIAP-BIR2 (with a KD of 15.8 nM for both). IAP ligand 8 serves as an IAP ligand moiety to synthesize IAP-recruiting protein degrader (IPD) (HY-181590). This IPD simultaneously forms two ternary complexes, cIAP1-A538-TEAD1 and XIAP-A538-TEAD1, and efficiently degrades TEAD1 via a dual E3 recruitment mechanism, while inducing the autodegradation of cIAP1. IAP ligand 8 and its series of degraders are applicable to targeted research on Hippo pathway-dysregulated cancers such as NF2-mutant mesothelioma .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
