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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
305 Results for "
bilayer
" in MedChemExpress (MCE) Product Catalog:
Products (305)
305 Results for "bilayer" in MCE Product Catalog:
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
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1 Cited Publications
Cat. No.: HY-W591461
DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
Cat. No.: HY-W040268
CAS No.: 923-61-5
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Cat. No.: HY-W440888
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DSPE-PEG2000-Folate (DSPE-PEG2000 Folate) is a folate-containing PEG derivative. DSPE-PEG2000-Folate possesses targeting activity and binds to folate receptors in cancer cells. DSPE-PEG2000-Folate can be post-inserted into preformed liposomal bilayers to prepare folate-targeted liposomal formulations. DSPE-PEG2000-Folate forms micelles/lipid bilayers and can be used in studies of targeted drug delivery systems [2].
Cat. No.: HY-W440896
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
Category:
Natural Products Psidium guajava Linn. Other Diseases Myrtaceae Plants Disease Research Fields
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Cat. No.: HY-P5366
Cat. No.: HY-D1425
CAS No.: 58293-56-4
Synonyms: 9-(2,2-Dicyanovinyl)julolidine
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DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells (Absorption/emission=489/505 nm) .
Cat. No.: HY-W013967
CAS No.: 1720-32-7
Cat. No.: HY-D1602
CAS No.: 217075-07-5
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BODIPY FL-DHPE is a fluorescent lipid probe composed of phosphatidylethanolamine (DHPE) labeled with a BODIPY FL fluorophore, which is used for fluorescent labeling of cell membranes, differentiation between liposome membrane fusion and endocytic pathways, and studies of membrane dynamics. The two C16 alkyl chains of BODIPY FL-DHPE insert into the lipid bilayer of membranes, and its fluorescence exhibits concentration dependence: it exists as monomers and emits green fluorescence at low mole fractions; it forms dimers with a red-shifted emission peak at high mole fractions; this spectral change is independent of enzymes, pH, and membrane potential. When liposomes enter the plasma membrane via membrane fusion, the dye is diluted, leading to attenuation of the dimer peak and enhancement of the monomer peak; when entry occurs via endocytosis, the dye remains in endosomes at high concentration with no change in the dimer peak, allowing differentiation between the two uptake pathways. Ex = 488 nm; monomer Em = 515 nm, dimer Em ≈ 620 nm .
Cat. No.: HY-W441007
CAS No.: 1360858-99-6
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DSPE-MAL is a phospholipid compound with a maleimide reactive group. DSPE-MAL contains two saturated fatty acids and can self-assemble in water to form a lipid bilayer. DSPE-MAL can be used to prepare liposomes as nanocarriers for active molecules .
Cat. No.: HY-D0074
CAS No.: 70504-01-7
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Prodan is an environment-sensitive fluorescent probe used to investigate the polarity, fluidity, and structure of lipid membranes. Prodan exhibits environment-dependent excitation/emission wavelengths, with its wavelength range covering Ex = 360-410 nm and Em = 430-530 nm when in solvents, bound to DNA, located in lipid bilayers, or associated with proteins. Prodan can interact with the major groove of DNA, regions of lipid bilayers, and hydrophobic pockets of proteins. During phase transitions, Prodan localizes to different regions of the bilayer: the emission minimum is 430-440 nm in the gel phase, while it shifts to 480-500 nm in the liquid-crystalline phase or interdigitated gel phase. When bound to rigid hydrophobic sites of proteins, the emission peak of Prodan undergoes a blue shift and its fluorescence intensity increases .
Cat. No.: HY-145539
CAS No.: 145849-32-7
1,2-Dipalmitoyl-sn-glycero-3-PS sodium is a phosphatidylserine phospholipid. 1,2-Dipalmitoyl-sn-glycero-3-PS sodium is used for the preparation of phospholipid bilayers .
Cat. No.: HY-W440982
CAS No.: 56421-10-4
Synonyms: PC(18:0/18:1); 2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine
SOPC (PC (18:0/18:1)) is a phosphatidylcholine lipid, which is an unsaturated phospholipid containing a cis double bond. When SOPC binds to Imatinib (HY-15463), Imatinib easily penetrates into its unsaturated liposome bilayer structure, and SOPC forms ordered, larger parallel stripe domains .
Cat. No.: HY-165029
CAS No.: 17708-90-6
Synonyms: PLPC
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1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC (PLPC) is a phosphatidylcholine phospholipid. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC and oxidized derivatives serve as models for investigating lipid peroxidation, membrane structure, and phospholipase A2 activity. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC can be applied in research on atherosclerosis, oxidative stress, and the properties of lipid bilayers .
Cat. No.: HY-122056
CAS No.: 39036-04-9
Synonyms: L-α-Diheptanoyllecithin; 12-Diheptanoyl-sn-glycero-3-PC
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1,2-Diheptanoyl-SN-glycero-3-phosphocholine (L-α-Diheptanoyllecithin; 12-Diheptanoyl-sn-glycero-3-PC) is a short-chain phospholipid. 11,2-Diheptanoyl-SN-glycero-3-phosphocholine forms bimolecular micelles with long-chain phospholipids, and these micelles undergo adsorption and spontaneous fusion to generate supported lipid bilayers. 1,2-Diheptanoyl-SN-glycero-3-phosphocholine enhances the transdermal penetration of hydrophilic low-molecular-weight compounds via micellar pretreatment of the skin of hairless mice. 1,2-Diheptanoyl-SN-glycero-3-phosphocholine can be used in studies of membrane biology, structural biology and transdermal drug delivery .
Ziapin 2 is a membrane potential modulator and an intracellular membrane photoactuator. Ziapin 2 binds to the bacterial plasma membrane, and upon embedding into the lipid bilayer, undergoes trans-cis isomerization under 470 nm light irradiation, which triggers membrane potential hyperpolarization and induces the opening of ion channels on bacterial cell membranes. Through interactions with lipids, Ziapin 2 increases the overall flexibility of the lipid bilayer. Ziapin 2 can form photosensitive transmembrane dimers to trigger cellular signal transduction. Ziapin 2 is applicable to the research and regulation of bacterial electrical signal transduction and the regulation of membrane physical properties .
Cat. No.: HY-W019833
CAS No.: 76343-22-1
Synonyms: PC(14:0/18:0); 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine
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Cat. No.: HY-W441013
DSPE-PEG1000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG1000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG1000-NHS can be used in the study of drug delivery .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
