DSPE-PEG2000-Folate
Based on 1 Customer Validation
DSPE-PEG2000-Folate (DSPE-PEG2000 Folate) is a folate-containing PEG derivative. DSPE-PEG2000-Folate possesses targeting activity and binds to folate receptors in cancer cells. DSPE-PEG2000-Folate can be post-inserted into preformed liposomal bilayers to prepare folate-targeted liposomal formulations. DSPE-PEG2000-Folate forms micelles/lipid bilayers and can be used in studies of targeted drug delivery systems[2].
For research use only. We do not sell to patients.
- Purity: 90.0%
- Molecular Weight:2000 (Average)
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Fatty Acids Compound Library
HY-L182
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High-Throughput Bioactive Compound Library
HY-L205
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Liposome Library
HY-L214
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Lipid Compound Library
HY-L043
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Anti-Breast Cancer Compound Library
HY-L074
Biological Activity
DSPE-PEG2000-Folate-modified FP(100)-PEG-Lipo (500 μM; 4 h) selectively enhances FITC-dextran delivery to folate receptor-positive HeLa cells compared to folate receptor-negative HaCaT cells, with uptake partially mediated by folate receptor binding[1].
DSPE-PEG2000-Folate-produced folate-modified Biotin and Folate microvesicle (BFMVs) enter MDA-MB-231 cells in a time-dependent manner, with 90% of cells taking up BFMVs by 2 h and maximum intracellular accumulation by 4 h at 37°C, and localize within the cell cytoplasm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 2000 (Average)
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(NCC(N=C23)=CNC3=NC(N)=NC2=O)C=C1)NC(C(O)=O)CCC(NCCOC(NCCOP(OC[C@@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kang MJ, et al. Folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation. Int J Nanomedicine. 2013;8:1155-65. [Content Brief]
[2]. Zhu L, et al. Folate-Engineered Microvesicles for Enhanced Target and Synergistic Therapy toward Breast Cancer. ACS Appl Mater Interfaces. 2017;9(6):5100-5108. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG2000-Folate Related Classifications
HY-W440888 Related Classifications
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