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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
275 Results for "
d18
" in MedChemExpress (MCE) Product Catalog:
Products (275)
275 Results for "d18" in MCE Product Catalog:
Cat. No.: HY-146933S
CAS No.: 2342574-54-1
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24:1 SM (d18:1/24:1)-d9 is deuterium labeled 24:1 SM (d18:1/24:1).
Cat. No.: HY-N15352
CAS No.: 222403-67-0
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Synonyms: C16 Ceramide-1-phosphate ammonium; Ceramide-1-phosphate (d18:1/16:0) ammonium; CerP(d18:1/16:0) ammonium
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C16 Ceramide-1-phosphate (d18:1/16:0) ammonium (C16 Ceramide-1-phosphate ammonium; Ceramide-1-phosphate (d18:1/16:0) ammonium) is an ester product that can be used to synthesize nanobiomaterials.
Cat. No.: HY-N8016S
CAS No.: 1466552-36-2
Cat. No.: HY-117081
CAS No.: 457100-08-2
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Cat. No.: HY-165075S
Cat. No.: HY-146931S
CAS No.: 2342574-48-3
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20:1 SM (d18:1/20:1)-d9 is deuterium labeled 20:1 SM (d18:1/20:1).
Cat. No.: HY-164236S
CAS No.: 2738376-81-1
Research Areas:
C22 Glucosylceramide (d18:1/22:0)-d4 is deuterium labeled C22 Glucosylceramide (d18:1/22:0) (HY-164236). C22 Glucosylceramide (d18:1/22:0) is a bioactive sphingolipid composed of a d18:1 sphingoid base and a 22:0 fatty acid chain. C22 Glucosylceramide (d18:1/22:0) specifically exists in Doxorubicin (HY-15142A)-sensitive cancer cells, and its circulating concentration is positively correlated with the incidence of cardiovascular events. C22 Glucosylceramide (d18:1/22:0) has been widely used in research related to cardiovascular diseases, hypercholesterolemia, metabolic syndrome, breast adenocarcinoma and other fields .
Cat. No.: HY-173119
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SKLB-D18 is an orally active ERK1/2/ERK5 inhibitor, with an IC50 of 38.69 nM and a Kd of 126.9 nM against human ERK1, an IC50 of 40.12 nM and a Kd of 209.8 nM against ERK2, and an IC50 of 59.72 nM and a Kd of 468.2 nM against ERK5. SKLB-D18 inhibits cancer cell proliferation, induces G0/G1 cell cycle arrest and apoptosis. SKLB-D18 reduces the levels of p-ERK5, p-RSKp90, p-c-Myc and c-Myc, and upregulates the level of p-ERK1/2, thereby inhibiting the ERK1/2/5 pathway in cells. SKLB-D18 increases LC3B-II accumulation, and decreases the levels of p62, p-mTOR and p-p70S6K. SKLB-D18 elevates the levels of ROS, lipid peroxidation and free ferrous ions, reduces the levels of NCOA4 and GPX4, and induces ferritin autophagy-dependent ferroptosis in cancer cells. SKLB-D18 exhibits antitumor activity in a triple-negative breast cancer xenograft mouse model. SKLB-D18 can be used in research related to triple-negative breast cancer .
Synonyms: DBUP-d18
Cat. No.: HY-124177AS
Research Areas:
C14 Ceramide (d18:1/14:0)-d7 is the deuterium labeled C14 Ceramide (d18:1/14:0) (HY-124177A). C14 Ceramide (d18:1/14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's and diabetes research .
Cat. No.: HY-152020S
CAS No.: 2377379-55-8
Synonyms: D-eytho-Sphigosie C18-d9
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Sphingosine-d9 (d18:1) (D-eytho-Sphigosie C18-d9) is deuterium labeled Sphingosine (d18:1) .
Cat. No.: HY-N15930
CAS No.: 1196670-47-9
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Cat. No.: HY-W023144S
CAS No.: 1447569-78-9
Synonyms: Tris(1-chloropropan-2-yl) phosphate-d18
Cat. No.: HY-179043S
CAS No.: 3056013-55-6
Synonyms: 18:1 DGDG-d18
Cat. No.: HY-153830S
CAS No.: 2097249-92-6
Synonyms: C16 Lactosylceramide (d18:1/16:0)-d3
Cat. No.: HY-177003
CAS No.: 121999-58-4
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Cat. No.: HY-156209S
CAS No.: 2738376-84-4
Research Areas:
Gb3(d18:1/16:0)-d9 is deuterium labeled Gb3(d18:1/16:0) (HY-156209). Gb3 (d18:1/16:0) (Compound 1) is the P k antigen of the P blood group system. Gb3 (d18:1/16:0) acts as a cell surface receptor. Gb3 (d18:1/16:0) is used for research on Burkitt's lymphoma, teratocarcinoma, embryonal carcinoma, and Fabry's disease .
Cat. No.: HY-N15950
CAS No.: 3056013-93-2
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Cat. No.: HY-145549
CAS No.: 121999-68-6
Synonyms: N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine; SM(d18:1/20:0)
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C20 Sphingomyelin (d18:1/20:0) (N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine; SM(d18:1/20:0)) is a naturally occurring sphingolipid. C20 Sphingomyelin (d18:1/20:0) levels are upregulated in the hippocampus of streptozotocin (HY-13753)-induced diabetic rats and in human plasma, positively correlating with insulin resistance in obese humans. C20 Sphingomyelin (d18:1/20:0) is also upregulated in the liver of a mouse model of Niemann-Pick C1 disease, a neurodegenerative cholesterol sphingolipid lysosomal storage disorder.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
