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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
nitrile
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "nitrile" in MCE Product Catalog:
Cat. No.: HY-E70919A
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Nitrile hydratase, Rhodopseudomonas palustris (EC 4.2.1.84) is a mononuclear iron or non-corrinoid cobalt enzyme that catalyse the hydration of diverse nitriles to their corresponding amides.
Cat. No.: HY-E70919B
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Nitrile hydratase, Rhodococcus erythropolis (EC 4.2.1.84) is a mononuclear iron or non-corrinoid cobalt enzyme that catalyse the hydration of diverse nitriles to their corresponding amides.
Cat. No.: HY-16641
CAS No.: 1315490-71-1
JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM). JAK1-IN-17 can be studied in cancer research .
Cat. No.: HY-W196977
CAS No.: 67886-70-8
Synonyms: Naproxen nitrile impurity
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Naproxen impurity 6 (Naproxen Nitrile impurity) is an impurity of Naproxen.
Cat. No.: HY-E70612
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Nitril hydratase can convert nitriles to the corresponding higher-value amides under mild conditions. Nitril hydratase is an important catalyst .
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Cat. No.: HY-P2872A
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Thioglucosidase, Sinapis alba (white mustard) seed (EC 3.2.1.147) hydrolyzes the S-glucosidic bond of a glucosinolate substrate to form an unstable aglycone that rearranges with the loss of sulfate primarily to the isothiocyanate, though thiocyanates and nitriles are also formed.
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3-(1-Cyanoethyl)benzoic acid (Standard) is the analytical standard of 3-(1-Cyanoethyl)benzoic acid. This product is intended for research and analytical applications. 3-(1-Cyanoethyl)benzoic acid (DF2107Y) is a benzoic acid that can be used to screen cobalt containing nitrile hydratases (NHases) .
Cat. No.: HY-125589
CAS No.: 1845688-96-1
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5N-Bicalutamide is an androgen receptor (AR) antagonist with a Ki of 0.15 nM. 5N-Bicalutamide is a derivative of Bicalutamide (HY-14249). 5N-Bicalutamide reacts with Cys784 in the AR binding pocket via an activated aryl nitrile group to form a reversible thioimidate covalent adduct, which significantly enhances its binding affinity and inhibitory potency. 5N-Bicalutamide is used in prostate cancer-related research .
Cat. No.: HY-W761397
CAS No.: 117568-28-2
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COMT-IN-3 is a competitive inhibitor of soluble catechol-O-methyltransferase (S-COMT). COMT-IN-3 coordinates with the Mg 2+ ion at the COMT active site via its catechol hydroxyl group, and its nitro group, as a strong electron-withdrawing substituent, further enhances the binding affinity. COMT-IN-3 interacts with the hydrophobic residues Trp38, Met40, and Trp143 at the back of the active site via its neutral nitrile tail, thereby competitively inhibiting COMT activity. COMT-IN-3 can be used in research related to Parkinson's disease .
Cat. No.: HY-L0118V
942 compounds
A unique set of molecules containing mild electrophilic moieties that covalently interact with amino acid residues in the target protein. The diversity of our compounds for covalent drug discovery ranges from natural product-like scaffolds to macrocycles, creating multiple opportunities in hit generation for a selected target.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
