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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
52 Results for "
probe design
" in MedChemExpress (MCE) Product Catalog:
Products (52)
52 Results for "probe design" in MCE Product Catalog:
Cat. No.: HY-D3003
CAS No.: 2522921-17-9
Cat. No.: HY-D3141
Cat. No.: HY-P11684
CAS No.: 172405-61-7
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Cat. No.: HY-156583
CAS No.: 21300-59-4
Synonyms: TPAC
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Thiophosphoro alkyne dichloridate (TPAC) is a thio-phosphonyl dichloride reagent based on the biomimetic design of histidine phosphorylation. Thiophosphoro alkyne dichloridate can selectively covalently couple with histidine and can be used for the development of protein function probes .
Cat. No.: HY-181455
CAS No.: 2309930-88-7
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rel-FTY720 phenoxy-biotin hydrochloride is a chemical probe designed based on the structure of Fingolimod (HY-12005), which incorporates a phenoxy group capable of specific click chemistry reactions and is conjugated with a biotin tag .
Cat. No.: HY-D2951
CAS No.: 2270958-94-4
Cat. No.: HY-D3346
Cat. No.: HY-113331F
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Thromboxane B2-biotin is an affinity probe that allows detection of thromboxane B2 through an interaction with the biotin ligand. Thromboxane B2-biotin is designed to allow thromboxane B2 to be detected in complexes with protein binding partners .
Cat. No.: HY-P11911
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Cat. No.: HY-W540123
CAS No.: 186046-82-2
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Cat. No.: HY-D2941
Synonyms: SNAP-AF
Cat. No.: HY-D3407
Cat. No.: HY-D3143
CAS No.: 2411524-33-7
Cat. No.: HY-D2939
CAS No.: 1622078-12-9
Cat. No.: HY-158616
CAS No.: 1286479-53-5
Cat. No.: HY-D2982
CAS No.: 1978301-38-0
Cat. No.: HY-D3224
CAS No.: 2413777-91-8
Cat. No.: HY-L945
74 compounds
Sulfonyl fluoride (-SO₂F) overcomes the poor target selectivity of traditional covalent warheads that rely heavily on cysteine. With high stability and tunable electrophilicity under physiological conditions, it targets multiple nucleophilic residues including Lys, Tyr, Ser and His, offering expanded druggable space, lower off-target risks and prolonged efficacy. It is widely used in covalent inhibitors, molecular glues, PROTACs and chemical probes.
MCE has built a highly diverse sulfonyl fluoride fragment library with 1,162 structurally diverse, drug-like fragments. Designed for balanced reactivity, stability and compatibility, these molecules feature tunable electrophilicity, simple scaffolds and high derivatization potential. Combined with SuFEx click chemistry, the library enables efficient modular modification and rapid structure optimization.
Ideal for targeting non-cysteine residues, this library improves covalent screening and probe development efficiency, serving as a precise tool for early-stage covalent drug discovery and chemical biology research.
Cat. No.: HY-P11688
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Cat. No.: HY-D3007
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
