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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
A2aR
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "A2aR" in MCE Product Catalog:
Cat. No.: HY-101980R
CAS No.: 1321514-06-0
Synonyms: HTL1071 (Standard); AZD4635 (Standard)
Research Areas:
Imaradenant (Standard) is the analytical standard of Imaradenant (HY-101980). This product is intended for research and analytical applications. AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors .
Cat. No.: HY-P706213
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: ADORA2A; Adenosine Receptor A2a; Prev. ADORA2; Adenosine Receptor A2; RDC8; A2aR; Adenosine A2a Receptor; Adenosine Receptor Subtype A2a
Species:
Human
Source:
HEK293
Cat. No.: HY-109139R
CAS No.: 1337962-47-6
Synonyms: NIR178 (Standard); PBF509 (Standard)
Research Areas:
Taminadenant (Standard) is the analytical standard of Taminadenant (HY-109139). This product is intended for research and analytical applications. Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparKinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response [2].
Cat. No.: HY-101978R
CAS No.: 1202402-40-1
Synonyms: CPI-444 (Standard); V81444 (Standard)
Research Areas:
Ciforadenant (Standard) is the analytical standard of Ciforadenant (HY-101978). This product is intended for research and analytical applications. Ciforadenant (CPI-444) is a potent, orally active and selective adenosine A2A receptor (A2AR) antagonist, which induces antitumor responses .
Cat. No.: HY-158882
CAS No.: 2820046-26-0
Research Areas:
FLAC6 is a potent fluorinated detergent that can be used to solubilize membrane proteins (the native adenosine receptor A2AR, a G protein-coupled receptor, and two native transporters AcrB and BmrA). FLAC6 can maintain the structural and functional integrity of different membrane proteins .
Cat. No.: HY-181877
Target:
Research Areas:
IHCH-3185 is an orally active class I HDAC inhibitor (HDAC1 IC50 =102.9 nM) and A2AR antagonist (A2AR Ki =7.6 nM). IHCH-3185 reverses immune gene silencing by inducing histone acetylation and blocks the adenosine signaling pathway to relieve T-cell suppression. IHCH-3185 exhibits antiproliferative activity, induces cell cycle arrest, and significantly improves the tumor microenvironment. IHCH-3185 reduces the proportion of regulatory T cells, increases the CD8 +/Treg ratio, and upregulates the expression of key factors such as H2-K1, Cxcl9 and Cxcl10. IHCH-3185 shows significant antitumor potential in CT26 and MC38 mouse tumor models and is suitable for related cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
