2. Others GPCR/G Protein
  3. Reference Standards Adenosine Receptor
  4. Taminadenant (Standard)

Taminadenant (Standard)  (Synonyms: NIR178 (Standard); PBF509 (Standard))

Cat. No.: HY-109139R
Handling Instructions Technical Support

Taminadenant (Standard) is the analytical standard of Taminadenant (HY-109139). This product is intended for research and analytical applications. Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparKinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response.

For research use only. We do not sell to patients.

Taminadenant (Standard)

Taminadenant (Standard) Chemical Structure

CAS No. : 1337962-47-6

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Information

Taminadenant (Standard) is the analytical standard of Taminadenant (HY-109139). This product is intended for research and analytical applications. Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparKinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

306.12

Formula

C10H8BrN7
CAS No.
SMILES

BrC(C(N1C=CC=N1)=NC(N2C=CC=N2)=N3)=C3N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Taminadenant (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taminadenant (Standard)1337962-47-6NIR178 (Standard) PBF509 (Standard)Reference StandardsAdenosine ReceptorP1 receptormovement disordersincluding catalepsytremorhemiparkinsonismantitumorInhibitorinhibitorinhibit

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