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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
910 Results for "
changes
" in MedChemExpress (MCE) Product Catalog:
Products (910)
910 Results for "changes" in MCE Product Catalog:
Cat. No.: HY-186151
CAS No.: 1372406-51-3
UCI-LC0019 is a mutant p53 reactivator. UCI-LC0019 binds to mutant p53, induces wild-type-like conformational change, restores sequence-specific DNA binding activity, activates p53-dependent transcription programs, and does not act via thiol reactivity or glutathione depletion. UCI-LC0019 inhibits proliferation and induces apoptosis in cancer cells harboring mutant p53, with no significant effect on p53 null or wild-type p53 tumors cells. UCI-LC0019 exhibits anti-tumor activity in xenograft mouse models carrying p53R175H mutant tumors. UCI-LC0019 can be used for the research of cancer, such as ovarian cancer .
Cat. No.: HY-187204
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RX-044 is a ROCK1/ROCK2 inhibitor with ROCK1 IC50 10.01 nM and ROCK2 IC50 9.68 nM, and demonstrates kinase selectivity. RX-044 induces reversible cell retraction, modulates cytoskeletal organization via F-actin depolymerization, inhibits cell contractility, and attenuates TGF-β2-induced cell migration. RX-044 preserves retinal ganglion cell survival, restores electroretinography responses, and ameliorates histopathological changes. RX-044 lowers intraocular pressure in a mouse ocular hypertension model. RX-044 shows no cytotoxicity in target cells. RX-044 exhibits initial ocular irritation that subsides with extended dosing. RX-044 can be used for the research of glaucoma .
Cat. No.: HY-188012
CAS No.: 2975602-21-0
Synonyms: dMGer
Desmethyl germinone (dMGer) is a KL signaling pathway activator that binds to the human HTL/KAI2 receptor with an IC50 of 46.4 nM. Desmethyl germinone induces conformational changes of the receptor by directly binding to the ligand-binding pocket of KAI2/D14L, promotes the interaction of KAI2/D14L with D3/MAX2 and SMAX1, and leads to SMAX1 degradation. Desmethyl germinone induces seed germination and inhibits hypocotyl elongation in an abscisic acid-independent manner in Arabidopsis thaliana, and inhibits mesocotyl elongation and induces the expression of KL-responsive genes in rice. Desmethyl germinone can be used in studies related to seed germination, dormancy, and the KAI2/KL signaling pathway .
Cat. No.: HY-189252
JAK2 activator 1 is an orally active and selective JAK2 activator derived from Proanthocyanidin A1 (HY-N2344) (EC50 = 64 nM). JAK2 activator 1 directly binds to JAK2, triggers conformational changes, and achieves allosteric activation of the JAK2/STAT3 signaling pathway. JAK2 activator 1 promotes hematopoietic recovery in chemotherapy-induced myelosuppression by protecting hematopoietic stem cells from Carboplatin (HY-17393)-induced damage. JAK2 activator 1 does not promote the proliferation of A549, HepG2, or CaCo2 tumor cells, nor does it attenuate the antitumor effect of Carboplatin. JAK2 activator 1 can be used in research related to cancer chemotherapy-induced myelosuppression .
Cat. No.: HY-B0113AR
CAS No.: 95510-70-6
Synonyms: H 16868 sodium (Standard)
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Reference Standards Na+/K+ ATPase Interleukin Related Proton Pump Cytochrome P450 Bacterial Apoptosis Autophagy TNF Receptor Atg8/LC3
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Omeprazole (sodium) (Standard) is the analytical standard of Omeprazole (sodium). This product is intended for research and analytical applications. Omeprazole sodium (H 16868) is an orally active H +,K +-ATPase inhibitor and a proton pump inhibitor. Omeprazole sodium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sodium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sodium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sodium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sodium aslo has neuroprotective and antibacterial effects .
Cat. No.: HY-B0113R
CAS No.: 73590-58-6
Synonyms: H 16868 (Standard)
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Reference Standards Na+/K+ ATPase Interleukin Related Proton Pump Cytochrome P450 Bacterial Apoptosis Autophagy TNF Receptor Atg8/LC3
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Omeprazole (Standard) is the analytical standard of Omeprazole. This product is intended for research and analytical applications. Omeprazole (H 16868) is an orally active H +,K +-ATPase inhibitor and a proton pump inhibitor. Omeprazole competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole aslo has neuroprotective and antibacterial effects .
Cat. No.: HY-B0113S4
Synonyms: H 16868-d3 sodium
Cat. No.: HY-D1556
CAS No.: 384832-91-1
Synonyms: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium
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18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .
Cat. No.: HY-D3086
CAS No.: 1668565-72-7
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Mito-polarity is a mitochondria-targeted polarity probe. Mito-polarity can be used to detect mitochondrial polarity. The detection mechanism of Mito-polarity is based on an intramolecular charge transfer (ICT) system designed with a donor-π-bridge-acceptor (D-π-A) structure. Among them, the 467 nm green emission generated by the Coumarin (HY-N0709) structure is extremely sensitive to polarity changes, while the 642 nm red emission produced by the extended π-conjugation and ICT effect between the Coumarin and benzothiazine structures shows only a weak response, thus forming a ratiometric fluorescence response that is linearly correlated with solvent polarity. When Mito-polarity is excited at 405 nm in methanol, its excitation/emission wavelengths are Ex/Em = 405/467 nm and Ex/Em = 405/642 nm, with maximum absorption wavelengths of 426 nm and 561 nm .
Cat. No.: HY-D3101
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Nile-TPA is a fluorescent probe for polarity detection, which can be used for lipid droplet targeting, cell polarity analysis, in vivo polarity imaging, and blood polarity monitoring in circulating tumor mouse models. The detection mechanism of Nile-TPA relies on the dual intramolecular charge transfer (ICT) effect generated by the electron-donating triphenylamine and Nile Red moieties and the electron-withdrawing carbonyl group; this probe emits strong red fluorescence in a low-polarity environment, and as polarity increases, the fluorescence intensity decreases and a red shift occurs due to changes in the excited-state dipole moment. In spectral tests, its excitation wavelength is 540 nm, and the emission wavelength varies in the range of 550-800 nm depending on solvent polarity; for cell, zebrafish and mouse imaging, Ex/Em = 561/570-620 nm, and for in vivo mouse imaging, Ex/Em = 560/620 nm .
Cat. No.: HY-D3104
CAS No.: 2767443-23-0
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ERNT is a fluorescent probe for monitoring endoplasmic reticulum (ER) polarity and detecting endoplasmic reticulum stress (ERS) during the progression of dynamic liver injury. ERNT functions based on a donor-π-acceptor (D-π-A) structure with an intramolecular charge transfer (ICT) effect. ERNT has multiple excitation/emission pairs: for in vitro cell imaging, the green channel has Ex/Em = 488/500-550 nm, and the red channel has Ex/Em = 488/570-620 nm; for in vivo liver imaging, Ex/Em = 520/620 nm; for solvent optical tests, Ex = 470 nm, with the maximum emission peak at 548 nm in low-polarity toluene and 668 nm in high-polarity DMSO. ERNT can evaluate the efficacy of hepatoprotective interventions by detecting changes in ER polarity, and also exhibits excellent photostability and low cytotoxicity .
Cat. No.: HY-D3112
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P2-Aggregate is a polarity-sensitive fluorescent probe for protein aggregation, which is based on the Nile Red scaffold and modified with a morpholine ring to enhance water solubility. P2-Aggregate improves anti-precipitation ability in aqueous phase via morpholine ring modification, and enables site-specific labeling of target proteins by combining with HaloTag technology. Utilizing the property that its emission wavelength blue-shifts with decreasing local polarity (excited at 543 nm), P2-Aggregate quantitatively detects changes in local polarity during protein aggregation and polarity heterogeneity inside aggregates in living cells. P2-Aggregate can be used in the research of diseases associated with the aggregation of Htt-110Q and SOD1 proteins, such as Huntington's disease and amyotrophic lateral sclerosis .
Cat. No.: HY-D3377
CAS No.: 1616953-95-7
Synonyms: LysoRhoNox
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HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for detecting Fe 2+ (ferrous iron ions), with excitation/emission wavelengths of Ex/Em = 550/575 nm. HMRhoNox-M exists in a non-fluorescent spirocyclic closed conformation under physiological pH conditions. Fe 2+ triggers the deoxidation of its N-oxide group, shifting the equilibrium toward the fluorescent quinone-type (TMHMR) open conformation. HMRhoNox-M shows selectivity for Fe 2+ over other metal ions, as well as biologically relevant reactive oxygen species, reactive sulfur species, reactive nitrogen species and reducing agents. HMRhoNox-M can penetrate cell membranes and localize to lysosomes, enabling the imaging of intracellular Fe 2+ fluctuations, transferrin-mediated labile iron accumulation, and lysosomal Fe 2+ changes associated with ferroptosis .
Cat. No.: HY-N9422
CAS No.: 936827-87-1
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Adenosine 3'-phosphate 5'-phosphosulfate triethylamine, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca 2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .
Cat. No.: HY-N9921
CAS No.: 163597-24-8
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Cat. No.: HY-P11107
CAS No.: 2375823-45-1
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Cat. No.: HY-P11298
CAS No.: 2120397-85-3
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N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a rate-limiting enzyme in bacteria metabolism that catalyzes the reversible aldol cleavage of sialic acid, and it regulates the overall metabolism of the bacterial sialic acid catabolic pathway. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation reaction of pyruvate and N-acetyl-d-mannosamine (ManNAc) to produce sialic acid N-acetylneuraminic acid (Neu5Ac). The protein expression of N-Acetylneuraminate lyase is downregulated at the translational level under the regulation of methyl methanesulfonate, and this change significantly impairs the adhesion and invasion abilities of bacteria to eukaryotic cells. N-Acetylneuraminate lyase is a key virulence-related protein in various pathogenic bacteria and is considered an antibiotic drug target. N-Acetylneuraminate lyase (CgNal) can be used in studies of invasive (extraintestinal) infectious diseases, Crohn's disease, and methicillin-resistant Staphylococcus aureus infections .
Cat. No.: HY-P4551
CAS No.: 31373-65-6
Synonyms: N-Benzoyl-Gly-His-Leu
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Cat. No.: HY-W009708R
CAS No.: 28588-75-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
