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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8391 Results for "
binding avidity
" in MedChemExpress (MCE) Product Catalog:
Products (8391)
8391 Results for "binding avidity" in MCE Product Catalog:
Cat. No.: HY-P86920
Synonyms: Basic domain helix loop helix protein class B 1 antibody; Basic helix loop helix protein class B 1 antibody; BHLHB antibody; bHLHB1 antibody; bHLHe19 antibody; Class B basic helix loop helix protein 1 antibody; Class B basic helix-loop-helix protein 1 antibody; class E basic helix loop helix protein 19 antibody; Class E basic helix-loop-helix protein 19 antibody; Human protein kinase C binding protein RACK17 antibody; Basic domain helix loop helix protein class B 1 antibody; Basic helix loop helix protein class B 1 antibody
Cat. No.: HY-L045
4,317 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.
HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.
MCE offers a unique collection of 4,317 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.
Cat. No.: HY-P702912
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: METTL3; Methyltransferase Like 3; Methyltransferase 3, N6-Adenosine-Methyltransferase Complex Catalytic Subunit; HMETTL3; MT-A70; CDNA FLJ58857, Highly Similar To N6-Adenosine-Methyltransferase 70 KDa Subunit; Spo8; CDNA FLJ57780, Highly Similar To N6-Adenosine-Methyltransferase 70 KDa Subunit; M6A; AdoMet-binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase; N(6)-Adenosine-Methyltransferase Catalytic Subunit METTL3; N6-Adenosine-Methyltransferase Catalytic Subunit; MRNA (2'-O-Methyladenosine-N(6)-)-Methyltransferase; MRNA M(6)A Methyltransferase; N(6)-Adenosine-Methyltransferase 70 KDa Subunit; MTA70; N6-Adenosine-Methyltransferase 70 KDa Subunit; IME4; Methyltransferase-Like Protein 3
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P85945
Synonyms: AV026640; BCH; Benign chorea; BHC; Homeobox protein NK 2 homolog A; Homeobox protein NK-2 homolog A; Homeobox protein Nkx 2.1; Homeobox protein Nkx-2.1; Homeobox protein Nkx2.1; NK 2; NK 2 homolog A; NK2; NK2 homeobox 1; NK2, drosophila, homolog of, A; NK2.1, Mouse, homolog of; Nkx 2 1; NKX 2.1; NKX 2A; NKX2 1; Nkx2-1; NKX2.1; NKX21_HUMAN; NKX2A; T EBP; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid nuclear factor; Thyroid specific enhancer binding protein; Thyroid transcription factor 1; Tin man; Tinman; TITF 1; TITF1; TTF 1; TTF-1; TTF1
Cat. No.: HY-P86155
Synonyms: AV026640; BCH; Benign chorea; BHC; Homeobox protein NK 2 homolog A; Homeobox protein NK-2 homolog A; Homeobox protein Nkx 2.1; Homeobox protein Nkx-2.1; Homeobox protein Nkx2.1; NK 2; NK 2 homolog A; NK2; NK2 homeobox 1; NK2, drosophila, homolog of, A; NK2.1, Mouse, homolog of; Nkx 2 1; NKX 2.1; NKX 2A; NKX2 1; Nkx2-1; NKX2.1; NKX21_HUMAN; NKX2A; T EBP; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid nuclear factor; Thyroid specific enhancer binding protein; Thyroid transcription factor 1; Tin man; Tinman; TITF 1; TITF1; TTF 1; TTF-1; TTF1
Cat. No.: HY-P86893
Synonyms: CJS antibody; Gli 2 antibody; GLI family zinc finger 2 antibody; GLI Kruppel family member GLI2 antibody; GLI2 antibody; GLI2_HUMAN antibody; Glioma associated oncogene family zinc finger antibody; HPE9 antibody; Oncogene GLI2 antibody; PHS2 antibody; CJS antibody; Gli 2 antibody; GLI family zinc finger 2 antibody; GLI Kruppel family member GLI2 antibody; GLI2 antibody; GLI2_HUMAN antibody; Glioma associated oncogene family zinc finger antibody; HPE9 antibody; Oncogene GLI2 antibody; PHS2 antibody; Tax helper protein 1 antibody; Tax helper protein 2 antibody; Tax helper protein antibody; Tax responsive element 2 holding protein antibody; Tax responsive element 25 bp sequence binding protein antibody; THP antibody; THP1 antibody; THP2 antibody; Zinc finger protein GLI2 antibody;
Cat. No.: HY-P811993
Synonyms: SPAG9; Sperm Associated Antigen 9; JIP-4; PHET; CT89; JLP; Cancer/Testis Antigen 89; Sperm Surface Protein; KIAA0516; SYD1; HLC4; JIP4; PIG6; HSS; C-Jun NH2-Terminal Kinase-Associated Leucine Zipper Protein; Mitogen-Activated Protein Kinase 8-Interacting Protein 4; C-Jun-Amino-Terminal Kinase-Interacting Protein 4; JNK-Associated Leucine-Zipper Protein; Human Lung Cancer Oncogene 6 Protein; Protein Highly Expressed In Testis; Proliferation-Inducing Gene 6; JNK/SAPK-Associated Protein; JNK Interacting Protein; Lung Cancer Oncogene 4; Max-binding Protein; Sunday Driver 1; MGC117291; MGC14967; MGC74461; FLJ13450; FLJ14006; FLJ26141; FLJ34602; HLC-6; C-Jun N-Terminal Kinase Protein-Associated Leucine-Zipper Protein; Proliferation-Inducing Protein 6; Sperm-Associated Antigen 9; JNK-Interacting Protein 4; Sperm Specific Protein; Sperm-Specific Protein; HLC-4 Protein; MAPK8IP4; HLC6
Cat. No.: HY-P811993A
Synonyms: SPAG9; Sperm Associated Antigen 9; JIP-4; PHET; CT89; JLP; Cancer/Testis Antigen 89; Sperm Surface Protein; KIAA0516; SYD1; HLC4; JIP4; PIG6; HSS; C-Jun NH2-Terminal Kinase-Associated Leucine Zipper Protein; Mitogen-Activated Protein Kinase 8-Interacting Protein 4; C-Jun-Amino-Terminal Kinase-Interacting Protein 4; JNK-Associated Leucine-Zipper Protein; Human Lung Cancer Oncogene 6 Protein; Protein Highly Expressed In Testis; Proliferation-Inducing Gene 6; JNK/SAPK-Associated Protein; JNK Interacting Protein; Lung Cancer Oncogene 4; Max-binding Protein; Sunday Driver 1; MGC117291; MGC14967; MGC74461; FLJ13450; FLJ14006; FLJ26141; FLJ34602; HLC-6; C-Jun N-Terminal Kinase Protein-Associated Leucine-Zipper Protein; Proliferation-Inducing Protein 6; Sperm-Associated Antigen 9; JNK-Interacting Protein 4; Sperm Specific Protein; Sperm-Specific Protein; HLC-4 Protein; MAPK8IP4; HLC6
Cat. No.: HY-P703083
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: HSP90AA1; Heat Shock 86 KDa; Prev. HSPC1; FLJ31884; Prev. HSPCA; HSP90A; Prev. HSPCAL4; HSP 86; HSP90N; HSP86; Hsp89; LAP-2; Hsp90; Heat Shock Protein 90kDa Alpha Family Class A Member 1; Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1; Heat Shock 90kD Protein 1, Alpha-Like 4; Epididymis Secretory Sperm binding Protein Li 65p; Heat Shock 90kD Protein, Alpha-Like 4; Epididymis Luminal Secretory Protein 52; HSP90AA1 Protein; Lipopolysaccharide-Associated Protein 2; HSPCAL1; Heat Shock Protein Family C Member 1; HSP89A; Heat Shock 90kDa Protein 1, Alpha; Hsp103; Renal Carcinoma Antigen NY-REN-38; EL52; Heat Shock 90kD Protein 1, Alpha; HSPN; Heat Shock Protein HSP 90-Alpha; LAP2; LPS-Associated Protein 2; Heat Shock Protein 90 Alpha Family Class A Member 1; HEL-S-65p
Species:
Human
Source:
E. coli
Cat. No.: HY-P706229
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90AA1; Heat Shock 86 KDa; Prev. HSPC1; FLJ31884; Prev. HSPCA; HSP90A; Prev. HSPCAL4; HSP 86; HSP90N; HSP86; Hsp89; LAP-2; Hsp90; Heat Shock Protein 90kDa Alpha Family Class A Member 1; Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1; Heat Shock 90kD Protein 1, Alpha-Like 4; Epididymis Secretory Sperm binding Protein Li 65p; Heat Shock 90kD Protein, Alpha-Like 4; Epididymis Luminal Secretory Protein 52; HSP90AA1 Protein; Lipopolysaccharide-Associated Protein 2; HSPCAL1; Heat Shock Protein Family C Member 1; HSP89A; Heat Shock 90kDa Protein 1, Alpha; Hsp103; Renal Carcinoma Antigen NY-REN-38; EL52; Heat Shock 90kD Protein 1, Alpha; HSPN; Heat Shock Protein HSP 90-Alpha; LAP2; LPS-Associated Protein 2; Heat Shock Protein 90 Alpha Family Class A Member 1; HEL-S-65p
Species:
Human
Source:
E. coli
Cat. No.: HY-P86801
Synonyms: C C motif chemokine 3 antibody; CCL 3 antibody; CCL3 antibody; CCL3_HUMAN antibody; Chemokine (C C motif) ligand 3 antibody; Chemokine C C motif ligand 3 antibody; Chemokine ligand 3 antibody; G0/G1 switch regulatory protein 19 1 antibody; G0/G1 switch regulatory protein 19-1 antibody; G0S19 1 antibody; C C motif chemokine 3 antibody; CCL 3 antibody; CCL3 antibody; CCL3_HUMAN antibody; Chemokine (C C motif) ligand 3 antibody; Chemokine C C motif ligand 3 antibody; Chemokine ligand 3 antibody; G0/G1 switch regulatory protein 19 1 antibody; G0/G1 switch regulatory protein 19-1 antibody; G0S19 1 antibody; G0S19 1 protein antibody; Heparin binding chemotaxis protein antibody; L2G25B antibody; LD78 alpha antibody; LD78-alpha(4-69) antibody; LD78alpha antibody; Macrophage inflammatory protein 1 alpha antibody; Macrophage inflammatory protein 1-alpha antibody; macrophage inflammatory protein 1a antibody; M; IP : 1 alpha antibody; M; IP : 1A antibody; MIP-1-alpha antibody; MIP-1-alpha(4-69) antibody; MIP1 alpha antibody; MIP1A antibody; PAT 464.1 antibody; SCYA 3 antibody; SCYA3 antibody; SIS alpha antibody; SIS beta antibody; SIS-beta antibody; Small inducible cytokine A3 antibody; small inducible cytokine A3 (homologous to mouse Mip-1a) antibody; Small-inducible cytokine A3 antibody; Tonsillar lymphocyte LD78 alpha protein antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
