904 Results for "

DNA damage,

" in MedChemExpress (MCE) Product Catalog:
Products (904)

904 Results for "DNA damage," in MCE Product Catalog:

1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide
1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide
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Cat. No.: HY-N20682
CAS No.: 2866266-56-8
Category:  

Terpenoids Sesquiterpenes Plants Compositae Extract Piptanthus nepalensis (Hook.) D. Don

Target:  

NO Synthase COX NF-κB Arginase

1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide is a neuroprotective agent. 1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide reduces the protein expression levels of iNOS and COX-2, blocks the DNA-binding activity of NF-κB, and inhibits nitric oxide production. 1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide promotes the polarization of microglia to the M2 phenotype by inducing the production of Arg-1, and alleviates cell damage induced by H2O2 and 6-Hydroxydopamine (HY-B1081) .
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Phellopterin
Phellopterin
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Cat. No.: HY-N2110
CAS No.: 2543-94-4
Category:  

Umbelliferae Extract Coumarins Phenylpropanoids Plants Helogyne apaloidea Nutt. Disease Research Fields Inflammation/Immunology

Target:  

Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV

Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .
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Phellopterin (Standard)
Phellopterin (Standard)
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Cat. No.: HY-N2110R
CAS No.: 2543-94-4
Category:  

Umbelliferae Extract Coumarins Phenylpropanoids Plants Helogyne apaloidea Nutt.

Target:  

Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV

Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.
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TRAIL R2/TNFRSF10B Protein, Human
TRAIL R2/TNFRSF10B Protein, Human
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Cat. No.: HY-P72779
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript Variant 1, MRNA; TRAIL-R2; P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer); TRAILR2; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9; KILLER; Death Domain Containing Receptor For TRAIL/Apo-2L; DR5; Apoptosis Inducing Protein TRICK2A/2B; Tumor Necrosis Factor Receptor Superfamily, Member 10b; Apoptosis Inducing Receptor TRAIL-R2; Tumor Necrosis Factor Receptor Superfamily Member 10B; Cytotoxic TRAIL Receptor-2; TRICK2A; TNFRSF10B Protein; TRICKB; Fas-Like Protein; CD262; TRAIL Receptor 2; TNF-Related Apoptosis-Inducing Ligand Receptor 2; CD262 Antigen; Death Receptor 5; KILLER/DR5; TRICK2; TRICK2B
Species:  
Human
Source:  
E. coli
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