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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
298 Results for "
SMAD
" in MedChemExpress (MCE) Product Catalog:
Products (298)
298 Results for "SMAD" in MCE Product Catalog:
Cat. No.: HY-W108953
CAS No.: 959610-24-3
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Cat. No.: HY-175662
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TGF-β/Smad-IN-2 is an orally active TGF-β/Smad inhibitor. TGF-β/Smad-IN-2 inhibits TGF-β-induced fibroblast-to-myofibroblast differentiation and collagen deposition, with an IC50 value of 102 μM for collagen reduction in LL29 cells. TGF-β/Smad-IN-2 exerts its effects through modulation
of the SMAD3/SMAD7 signaling pathway. TGF-β/Smad-IN-2 reduces lung index in pulmonary fibrosis mice. TGF-β/Smad-IN-2 can be used for the study of pulmonary fibrosis .
Cat. No.: HY-179042
CAS No.: 3100351-69-4
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TGF-β/Smad-IN-3 (Compound 4w) is an effective TGF-β/Smad inhibitor. TGF-β/Smad-IN-3 exerts anti-pulmonary fibrosis activity by simultaneously inhibiting the TGF-β/Smad and MAPK signaling pathways. TGF-β/Smad-IN-3 significantly inhibits collagen deposition induced by TGF-β1, with its IC50 value being 3.21 μM. TGF-β/Smad-IN-3 has an IC₅₀ of 46.77 nM for the autocrine motility factor (ATX). TGF-β/Smad-IN-3 significantly reduces the expression levels of α-SMA, COL1A1 and FN in TGF-β1-induced CCC-HPF-1 cells, and effectively inhibited TGF-β1-induced cell migration. TGF-β/Smad-IN-3 can be used for the study of pulmonary fibrosis .
Cat. No.: HY-176737
CAS No.: 3097194-50-5
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TGF-β1/Smad-IN-1 (compound C9) is a potent TGF-β1/Smad inhibitor. TGF-β1/Smad-IN-1 inhibits the expression of fibrosis markers (α-SMA and COL1A1) induced by TGF-β1. TGF-β1/Smad-IN-1 shows antifibrotic effects. TGF-β1/Smad-IN-1 has the potential for the research of hepatic fibrosis .
Cat. No.: HY-P11223
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Cat. No.: HY-N2033R
CAS No.: 18942-26-2
Cat. No.: HY-118528
CAS No.: 864374-00-5
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TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells .
Cat. No.: HY-RS13392
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SMAD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS13394
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SMAD3 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS13396
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SMAD5 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS13399
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SMAD9 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17208
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Smad2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17346
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Smad4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19036
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Smad9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20491
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Smad5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23660
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Smad2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23800
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Smad4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24664
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Smad1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24888
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Smad6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26999
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Smad5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
