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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
110 Results for "
Terminal alkynes
" in MedChemExpress (MCE) Product Catalog:
Products (110)
110 Results for "Terminal alkynes" in MCE Product Catalog:
Cat. No.: HY-W591376
CAS No.: 2201825-22-9
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Azido-PEG19-azide is a click chemistry reagent with two terminal azide groups. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry.
Cat. No.: HY-W800807
CAS No.: 2135330-71-9
Cat. No.: HY-N15944
CAS No.: 2260670-21-9
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Cat. No.: HY-W800706
CAS No.: 2644752-90-7
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Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Cat. No.: HY-D3584
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AF647 Picolyl Azide is a far-red fluorescent probe used in bioorthogonal click chemistry. It reacts with terminal alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The integrated picolyl group chelates copper, which speeds up the reaction and allows for lower copper concentrations to protect sensitive proteins (Ex/Em = 650/665 nm)[1].
Cat. No.: HY-W190738
CAS No.: 857892-34-3
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Azide-PEG8-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry motif which is used to react with terminal alkynes or strained cyclooctynes.
Cat. No.: HY-184364
CAS No.: 2989205-54-9
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Photoclick stearic acid is a bifunctional lipid probe derived from stearic acid, containing a photo-activatable diazirine group and a terminal clickable alkyne moiety. Photoclick stearic acid can be used as a chemical reporter to investigate protein lipidation and analyze membrane protein-protein interactions .
Cat. No.: HY-W592010
CAS No.: 1807539-11-2
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C18-PEG4-Azide is a hybrid linker featuring a hydrophobic C18 chain, a hydrophilic PEG4 spacer, and an azide. The azide is reactive with terminal alkynes or strained cyclooctynes such as DBCO or BCN through click chemistry.
Cat. No.: HY-W336992
CAS No.: 17170-26-2
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2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione is a phthalimide with a terminal propargyl group connected by a 6-carbon linker. The alkyne can participate in copper-catalyzed Click Chemistry.
Cat. No.: HY-W598194
CAS No.: 1355510-12-1
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1-((4-Azidobutoxy)methyl)-4-methoxybenzene is a compound with a methyl phenol group and a butyl tail ending in a terminal azide. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
Cat. No.: HY-W197430
CAS No.: 65374-10-9
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Ethyl 6-azidohexanoate comprises an ethyl ester and a terminal azide group with a 5-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
Cat. No.: HY-W598199
CAS No.: 51453-79-3
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Ethyl 4-azidobutyrate comprises an ethyl ester and a terminal azide group with a 3-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
Cat. No.: HY-W800709
CAS No.: 2803119-06-2
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N-(acid-PEG10)-N-bis(PEG10-azide) is a very popular PEG reagent containing a terminal carboxylic acid and two azide groups. The hydrophilic PEG spacer increases solubility in aqueous media. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Cat. No.: HY-W800691
CAS No.: 2644752-83-8
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BP Fluor 350 Picolyl Azide is a blue-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
Cat. No.: HY-W598192
CAS No.: 1184934-40-4
Synonyms: 4-Azidobutyl benzoate
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1-Butanol, 4-azido-, 1-benzoate (4-Azidobutyl benzoate) is a compound with an ethyl benzoate head and a terminal azide group. The ethyl benzoate protected carboxyl group can be deprotected under acidic conditions. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.
Cat. No.: HY-W591360
CAS No.: 1240737-77-2
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Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
Cat. No.: HY-W800770
CAS No.: 2563610-26-2
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MB 543 DBCO is a fluroescent agent with a terminal DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. MB 543 Alkyne is a very hydrophilic, water-soluble, orange fluorescent dye that has a maximal absorption of 543 nm and emission at 566 nm. The compound is also pH insensitive from pH 3 to pH 10.
Cat. No.: HY-L258
437 compounds
In modern medicinal chemistry and chemical biology research, alkyne (-C≡C-) structures play an important role in click chemistry, bioorthogonal labeling, and the construction of functional molecules due to their unique linear geometry and high reactivity. In particular, driven by the development of copper-catalyzed azide-alkyne cycloaddition (CuAAC) and copper-free click reactions (SPAAC), terminal alkyne groups have become important “chemical handles” for building complex biomolecular systems.
The MCE Alkyne Compound Library contains 437 compounds designed for the construction of click chemistry reaction systems and the development of diverse functional molecules. In drug discovery, these structures serve as key reactive sites that can efficiently undergo click reactions with azide groups, enabling modular assembly of PROTAC molecules, construction of ADC linkers, and rapid synthesis of bioorthogonal labeling probes. In addition, alkyne groups exhibit high stability, mild reaction conditions, and excellent biocompatibility, allowing them to maintain reactivity in complex biological environments. This contributes to improved efficiency and controllability in drug development, making them indispensable chemical building blocks in modern drug design and functional molecular engineering.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
